Cloned (Comment) | Organism |
---|---|
wild-type and R391A mutant | Escherichia coli |
Crystallization (Comment) | Organism |
---|---|
- |
Escherichia coli |
Protein Variants | Comment | Organism |
---|---|---|
R391A | increased Km for 7,8-diaminopelargonic acid, no significantly altered crystal structure | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7-Keto-8-aminopelargonic acid | - |
Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
8-Amino-7-oxononanoate | pH 9, 25°C, wild-type enzyme | Escherichia coli | |
0.15 | - |
S-adenosyl-L-methionine | pH 9, 25°C | Escherichia coli | |
0.23 | - |
8-Amino-7-oxononanoate | pH 9, 25°C, R391A murant | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | Escherichia coli | biotin synthesis | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | transfer of alpha-amino group from S-adenosyl-L-methionine to KAPA | Escherichia coli | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | biotin synthesis | Escherichia coli | S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0021 | - |
8-Amino-7-oxononanoate | pH 9, 25°C, R391A mutant | Escherichia coli | |
0.013 | - |
8-Amino-7-oxononanoate | pH 9, 25°C, wild-type enzyme | Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
2 | - |
7-Keto-8-aminopelargonic acid | value above 2, pH 9, 25°C, R391A mutant | Escherichia coli |