KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.33 | - |
alpha-ketomethiobutyrate | 37°C | Trypanosoma brucei | |
0.33 | - |
alpha-ketomethiobutyrate | 37°C | Crithidia fasciculata | |
0.57 | - |
L-tyrosine | 37°C | Trypanosoma brucei | |
0.57 | - |
L-tyrosine | 37°C | Crithidia fasciculata | |
1.64 | - |
L-tryptophan | 37°C | Trypanosoma brucei | |
1.64 | - |
L-tryptophan | 37°C | Crithidia fasciculata | |
2.18 | - |
phenylalanine | 37°C | Trypanosoma brucei | |
2.18 | - |
phenylalanine | 37°C | Crithidia fasciculata |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-ketomethiobutyrate + phenylalanine | Trypanosoma brucei | best amino donor | methionine + phenylpyruvate | - |
? | |
alpha-ketomethiobutyrate + phenylalanine | Crithidia fasciculata | best amino donor | methionine + phenylpyruvate | - |
? | |
alpha-ketomethiobutyrate + tryptophan | Trypanosoma brucei | - |
methionine + indolepyruvate | - |
? | |
alpha-ketomethiobutyrate + tryptophan | Crithidia fasciculata | - |
methionine + indolepyruvate | - |
? | |
alpha-ketomethiobutyrate + tyrosine | Trypanosoma brucei | probably involved in the recycling of methionine after the synthesis of polyamines | methionine + hydroxyphenylpyruvate | - |
? | |
alpha-ketomethiobutyrate + tyrosine | Crithidia fasciculata | probably involved in the recycling of methionine after the synthesis of polyamines | methionine + hydroxyphenylpyruvate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crithidia fasciculata | - |
- |
- |
Mus musculus | - |
- |
- |
Trypanosoma brucei | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-ketomethiobutyrate + L-glutamine | best amino donor | Mus musculus | 2-oxoglutaramide + L-methionine | - |
? | |
alpha-ketomethiobutyrate + L-glutamine | 18% of activity with phenylalanine | Trypanosoma brucei | 2-oxoglutaramide + L-methionine | - |
? | |
alpha-ketomethiobutyrate + L-glutamine | 36% of activity with phenylalanine | Crithidia fasciculata | 2-oxoglutaramide + L-methionine | - |
? | |
alpha-ketomethiobutyrate + L-phenylalanine | - |
Mus musculus | L-methionine + phenylpyruvate | - |
? | |
alpha-ketomethiobutyrate + L-phenylalanine | best amino donor | Trypanosoma brucei | L-methionine + phenylpyruvate | - |
? | |
alpha-ketomethiobutyrate + L-phenylalanine | best amino donor | Crithidia fasciculata | L-methionine + phenylpyruvate | - |
? | |
alpha-ketomethiobutyrate + L-tryptophan | - |
Mus musculus | L-methionine + indolepyruvate | - |
? | |
alpha-ketomethiobutyrate + L-tryptophan | - |
Trypanosoma brucei | L-methionine + indolepyruvate | - |
? | |
alpha-ketomethiobutyrate + L-tryptophan | - |
Crithidia fasciculata | L-methionine + indolepyruvate | - |
? | |
alpha-ketomethiobutyrate + L-tyrosine | - |
Mus musculus | L-methionine + hydroxyphenylpyruvate | - |
? | |
alpha-ketomethiobutyrate + L-tyrosine | - |
Trypanosoma brucei | L-methionine + hydroxyphenylpyruvate | - |
? | |
alpha-ketomethiobutyrate + L-tyrosine | - |
Crithidia fasciculata | L-methionine + hydroxyphenylpyruvate | - |
? | |
alpha-ketomethiobutyrate + phenylalanine | best amino donor | Trypanosoma brucei | methionine + phenylpyruvate | - |
? | |
alpha-ketomethiobutyrate + phenylalanine | best amino donor | Crithidia fasciculata | methionine + phenylpyruvate | - |
? | |
alpha-ketomethiobutyrate + tryptophan | - |
Trypanosoma brucei | methionine + indolepyruvate | - |
? | |
alpha-ketomethiobutyrate + tryptophan | - |
Crithidia fasciculata | methionine + indolepyruvate | - |
? | |
alpha-ketomethiobutyrate + tyrosine | probably involved in the recycling of methionine after the synthesis of polyamines | Trypanosoma brucei | methionine + hydroxyphenylpyruvate | - |
? | |
alpha-ketomethiobutyrate + tyrosine | probably involved in the recycling of methionine after the synthesis of polyamines | Crithidia fasciculata | methionine + hydroxyphenylpyruvate | - |
? | |
arginine + alpha-ketomethiobutyrate | - |
Crithidia fasciculata | ? + methionine | - |
? | |
L-alanine + alpha-ketomethiobutyrate | - |
Trypanosoma brucei | pyruvate + L-methionine | - |
? | |
L-alanine + alpha-ketomethiobutyrate | - |
Crithidia fasciculata | pyruvate + L-methionine | - |
? | |
L-aspartate + alpha-ketomethiobutyrate | - |
Trypanosoma brucei | oxaloacetate + L-methionine | - |
? | |
L-aspartate + alpha-ketomethiobutyrate | - |
Crithidia fasciculata | oxaloacetate + L-methionine | - |
? | |
L-cysteine + alpha-ketomethiobutyrate | - |
Trypanosoma brucei | 2-oxo-3-thiopropanoate + L-methionine | - |
? | |
L-cysteine + alpha-ketomethiobutyrate | - |
Crithidia fasciculata | 2-oxo-3-thiopropanoate + L-methionine | - |
? | |
L-histidine + alpha-ketomethiobutyrate | - |
Crithidia fasciculata | 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-methionine | - |
? | |
L-isoleucine + alpha-ketomethiobutyrate | - |
Crithidia fasciculata | 3-methyl-2-oxo-pentanoate + L-methionine | - |
? | |
L-lysine + alpha-ketomethiobutyrate | - |
Crithidia fasciculata | 2-oxo-6-amino-hexanoate + L-methionine | - |
? | |
L-valine + alpha-ketomethiobutyrate | - |
Crithidia fasciculata | 3-methyl-2-oxo-butanoate + L-methionine | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxamine 5'-phosphate | - |
Mus musculus | |
pyridoxamine 5'-phosphate | - |
Trypanosoma brucei | |
pyridoxamine 5'-phosphate | - |
Crithidia fasciculata |