Protein Variants | Comment | Organism |
---|---|---|
G170R | mutation associated with primary hyperoxaluria type I, no effect on affinity for pyridoxal 5-phosphate | Homo sapiens |
G41R | mutation associated with primary hyperoxaluria type I, enhanced activity after re-folding | Homo sapiens |
G41V | mutation associated with primary hyperoxaluria type I, enhanced activity after re-folding | Homo sapiens |
I340M | polymorphism associated with enzyme from minor allele, significantly higher Km-value than that for major allele, 90% of activity of enzyme from major allele | Homo sapiens |
P11L | 50% of activity of enzyme from major allele | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Homo sapiens | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
overexpression in Escherichia coli | - |
Renatured (Comment) | Organism |
---|---|
denaturation of enzyme with guanidine-HCl and re-folding, complete renaturation. Mutations G41V and G41R, associated with primary hyperoxaluria type I, show enhanced activity after re-folding. Pyridoxal 5-phosphate is not required for proper re-folding | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |