Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E235A | mutant retains its regiospecificity for the gamma-amino group of ornithine, but the glutamate reaction is enhanced 650fold, whereas only a 5fold enhancement of the ketoglutarate reaction rate results | Homo sapiens |
E235S | mutation leads to a lowering of the apparent rate and an increase of the dissociation constant | Homo sapiens |
Y85I | mutation greatly affects the ketoglutarate reaction but has no effect on the glutamate reaction | Homo sapiens |
Y85L | significant decrease in reactivity toward ornithine | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P04181 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine + 2-oxoglutarate | - |
Homo sapiens | DELTA1-pyrroline-5-carboxylate + L-glutamate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
Orn-AT | - |
Homo sapiens |
ornithine aminotransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | 0.02 mM, required for activity | Homo sapiens |