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Literature summary for 2.5.1.7 extracted from
- Molecular modelling and dynamic simulation of UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) from Mycobacterium tuberculosis using in silico approach (2018), Inform. Med. Unlocked, 12, 56-66 .
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ZINC11784805 | - |
Mycobacterium tuberculosis |  |
| ZINC11870141 | - |
Mycobacterium tuberculosis | |
| ZINC11911651 | - |
Mycobacterium tuberculosis | |
| ZINC11996545 | - |
Mycobacterium tuberculosis | |
| ZINC12029128 | - |
Mycobacterium tuberculosis | |
| ZINC12217441 | - |
Mycobacterium tuberculosis | |
| ZINC12247644 | - |
Mycobacterium tuberculosis | |
| ZINC12283251 | - |
Mycobacterium tuberculosis | |
| ZINC14531471 | - |
Mycobacterium tuberculosis | |
| ZINC14538153 | - |
Mycobacterium tuberculosis | |
| ZINC14541533 | - |
Mycobacterium tuberculosis | |
| ZINC14733773 | - |
Mycobacterium tuberculosis | |
| ZINC14742779 | - |
Mycobacterium tuberculosis | |
| ZINC15072755 | - |
Mycobacterium tuberculosis | |
| ZINC19334116 | - |
Mycobacterium tuberculosis | |
| ZINC19731417 | - |
Mycobacterium tuberculosis | |
| ZINC20038502 | - |
Mycobacterium tuberculosis | |
| ZINC20256175 | - |
Mycobacterium tuberculosis | |
| ZINC633838 | - |
Mycobacterium tuberculosis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine | Mycobacterium tuberculosis | - |
phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine | - |
? | |
| phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine | Mycobacterium tuberculosis ATCC 25618 | - |
phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | P9WJM1 | - |
- |
| Mycobacterium tuberculosis ATCC 25618 | P9WJM1 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine | - |
Mycobacterium tuberculosis | phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine | - |
? | |
| phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine | - |
Mycobacterium tuberculosis ATCC 25618 | phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MurA | - |
Mycobacterium tuberculosis |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000007324 | - |
ZINC12217441 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00001366 | - |
ZINC11996545 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00001535 | - |
ZINC20256175 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00001744 | - |
ZINC12283251 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00002778 | - |
ZINC19334116 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00005533 | - |
ZINC14538153 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.0000769 | - |
ZINC19731417 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.0000859 | - |
ZINC11870141 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00010559 | - |
ZINC14531471 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00013367 | - |
ZINC11784805 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00014949 | - |
ZINC15072755 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00016201 | - |
ZINC20038502 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00022235 | - |
ZINC11911651 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00032638 | - |
ZINC14733773 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00037659 | - |
ZINC14742779 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00044742 | - |
ZINC14541533 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00044905 | - |
ZINC12247644 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00059618 | - |
ZINC12029128 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
| 0.00100003 | - |
ZINC633838 | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
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