Literature summary for 2.5.1.55 extracted from

Araujo, J.O.; Dos Santos, A.M.; Lameira, J.; Alves, C.N.; Lima, A.H.
Computational Investigation of bisphosphate inhibitors of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (2019), Molecules, 24, 2370 .

Search for more literature for 2.5.1.55

Crystallization (Commentary)

Crystallization (Comment)	Organism
homology modeling based on the crystal structure of the KDO8P synthase from Escherichia coli, PDB entry 1X6U	Neisseria meningitidis serogroup B

Inhibitors

Inhibitors	Comment	Organism	Structure
1-[carboxy[(phosphonooxy)methyl]amino]-1-deoxy-6-O-phosphono-D-mannitol	i.e. BPH1, the phosphate group of BPH1 interacts with Lys133 and Arg163, while the carboxylate group of BPH1 interacts with Lys50, Lys55, and His197. Inhibitor shows the highest affinity among the inhibitors tested	Neisseria meningitidis serogroup B
2,8-bis(phosphonooxy)octanoic acid	i.e. BPH2, the phosphate group of BPH2 interacts with Lys133 and Arg163, while the carboxylate group of BPH2 interacts with Lys55, and His197	Neisseria meningitidis serogroup B
3-deoxy-2,8-di-O-phosphono-D-manno-octonic acid	i.e. BPH2, the phosphate group of BPH3 interacts with Lys133 and Arg163, while the carboxylate group of BPH3 interacts with Lys55, and His197	Neisseria meningitidis serogroup B

Organism

Organism	UniProt	Comment	Textmining
Neisseria meningitidis serogroup B	Q9JZ55	-	-
Neisseria meningitidis serogroup B MC58	Q9JZ55	-	-

Synonyms

Synonyms	Comment	Organism
KdsA	-	Neisseria meningitidis serogroup B

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Release 2023.1 (January 2023)