Literature summary for 2.5.1.54 extracted from

Sterritt, O.; Lang, E.; Kessans, S.; Ryan, T.; Demeler, B.; Jameson, G.; Parker, E.
Structural and functional characterisation of the entry point to pyocyanin biosynthesis in Pseudomonas aeruginosa defines a new 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase subclass (2018), Biosci. Rep., 38, BSR20181605 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
structure of type II DAH7PS, encoded by phzC as part of the duplicated phenazine biosynthetic cluster, to 2.7 A resolution, space group C2221 with two DAH7PS chains present in the asymmetric unit	Pseudomonas aeruginosa

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.016	-	D-erythrose 4-phosphate	pH 7.5, 37°C, presence of Co2+	Pseudomonas aeruginosa
0.017	-	phosphoenolpyruvate	pH 7.5, 37°C, presence of Co2+	Pseudomonas aeruginosa

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Co2+	-	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	G3XCJ9	-	-
Pseudomonas aeruginosa DSM 22644	G3XCJ9	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O	-	Pseudomonas aeruginosa	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate	-	?
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O	-	Pseudomonas aeruginosa DSM 22644	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
DAH7PS	-	Pseudomonas aeruginosa
phzC	-	Pseudomonas aeruginosa

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
45	-	-	Pseudomonas aeruginosa

Temperature Range [°C]

Temperature Minimum [°C]	Temperature Maximum [°C]	Comment	Organism
35	50	-	Pseudomonas aeruginosa

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
19.8	-	D-erythrose 4-phosphate	pH 7.5, 37°C, presence of Co2+	Pseudomonas aeruginosa

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	-	Pseudomonas aeruginosa

pH Range

pH Minimum	pH Maximum	Comment	Organism
6.5	7.5	-	Pseudomonas aeruginosa

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
1160	-	D-erythrose 4-phosphate	pH 7.5, 37°C, presence of Co2+	Pseudomonas aeruginosa
1240	-	phosphoenolpyruvate	pH 7.5, 37°C, presence of Co2+	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)