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Literature summary for 2.5.1.152 extracted from

  • Ghssein, G.; Brutesco, C.; Ouerdane, L.; Fojcik, C.; Izaute, A.; Wang, S.; Hajjar, C.; Lobinski, R.; Lemaire, D.; Richaud, P.; Voulhoux, R.; Espaillat, A.; Cava, F.; Pignol, D.; Borezee-Durant, E.; Arnoux, P.
    Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus (2016), Science, 352, 1105-1109 .
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Staphylococcus aureus A0A0H3JXA8
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-
Staphylococcus aureus ATCC 700699 A0A0H3JXA8
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + D-histidine
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 Staphylococcus aureus N-[(3S)-3-amino-3-carboxypropyl]-D-histidine + S-methyl-5'-thioadenosine
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 ?
S-adenosyl-L-methionine + D-histidine
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 Staphylococcus aureus ATCC 700699 N-[(3S)-3-amino-3-carboxypropyl]-D-histidine + S-methyl-5'-thioadenosine
-
 ?

Synonyms

Synonyms Comment Organism
cntL
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 Staphylococcus aureus

General Information

General Information Comment Organism
physiological function the enzyme participates in the biosynthesis of the metallophore staphylopine. Staphylopine biosynthesis is impaired in the CntL mutant. The import of iron, zinc, nickel, and cobalt are all decreased in CntL mutants. CntL mutant strains are resistant to a concentration of cobalt that is toxic to the wild-type strain Staphylococcus aureus