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Literature summary for 2.5.1.1 extracted from

  • Rubat, S.; Varas, I.; Sepulveda, R.; Almonacid, D.; Gonzalez-Nilo, F.; Agosin, E.
    Increasing the intracellular isoprenoid pool in Saccharomyces cerevisiae by structural fine-tuning of a bifunctional farnesyl diphosphate synthase (2017), FEMS Yeast Res., 17, fox032 .
    View publication on PubMed
Search for more literature for 2.5.1.1

Protein Variants

Protein Variants Comment Organism
A99H the strain carrying the variant shows significant differences on geranyl diphosphate concentrations and specific growth rate Saccharomyces cerevisiae
A99K the strain carrying the mutant enzyme accumulates high amounts of dimethylallyl diphosphate-isopentenyl diphosphate, with a decrease in geranyl diphosphate and farnesyl diphosphate Saccharomyces cerevisiae
A99Q the strain carrying the mutant enzyme accumulates high amounts of dimethylallyl diphosphate-isopentenyl diphosphate, with a decrease in geranyl diphosphate and farnesyl diphosphate Saccharomyces cerevisiae
A99R the strain carrying the variant shows significant differences on geranyl diphosphate concentrations and specific growth rate Saccharomyces cerevisiae
A99T the strain carrying the variant produces unquantifiable amounts of farnesyl diphosphate and no effect on geranyl diphosphate production is observed Saccharomyces cerevisiae
A99Y the strain carrying the mutant enzyme accumulates high amounts of dimethylallyl diphosphate-isopentenyl diphosphate, with a decrease in geranyl diphosphate and farnesyl diphosphate Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dimethylallyl diphosphate + isopentenyl diphosphate Saccharomyces cerevisiae the enzyme catalyzes the sequential condensation of two molecules of isopentenyl diphosphate (IPP) with dimethylallyl diphosphate (DMAPP), producing geranyl diphosphate (GPP) and farnesyl diphosphate diphosphate + geranyl diphosphate
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 ?
geranyl diphosphate + isopentenyl diphosphate Saccharomyces cerevisiae reaction of EC 2.5.1.10. The enzyme catalyzes the sequential condensation of two molecules of isopentenyl diphosphate (IPP) with dimethylallyl diphosphate (DMAPP), producing geranyl diphosphate (GPP) and farnesyl diphosphate diphosphate + (2E,6E)-farnesyl diphosphate
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 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dimethylallyl diphosphate + isopentenyl diphosphate the enzyme catalyzes the sequential condensation of two molecules of isopentenyl diphosphate (IPP) with dimethylallyl diphosphate (DMAPP), producing geranyl diphosphate (GPP) and farnesyl diphosphate Saccharomyces cerevisiae diphosphate + geranyl diphosphate
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 ?
geranyl diphosphate + isopentenyl diphosphate reaction of EC 2.5.1.10. The enzyme catalyzes the sequential condensation of two molecules of isopentenyl diphosphate (IPP) with dimethylallyl diphosphate (DMAPP), producing geranyl diphosphate (GPP) and farnesyl diphosphate Saccharomyces cerevisiae diphosphate + (2E,6E)-farnesyl diphosphate
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 ?

Synonyms

Synonyms Comment Organism
ERG20
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
metabolism farnesyl diphosphate synthase is a key enzyme responsible for the supply of isoprenoid precursors for several essential metabolites, including sterols, dolichols and ubiquinone Saccharomyces cerevisiae