Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | N-linked glycosylation occurs in the endoplasmic reticulum lumen by the membrane associated oligosaccharyltransferase enzyme complex | Homo sapiens | 5783 | - |
endoplasmic reticulum | N-linked glycosylation occurs in the endoplasmic reticulum lumen by the membrane associated oligosaccharyltransferase enzyme complex | Saccharomyces cerevisiae | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P46977 AND P0C6T2 AND P61165 AND P61803 AND P04843 AND P04844 AND P39656 AND Q9NRP0 | oligosaccharyltransferase A complex (catalytic subunit). P46977: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3A. P0C6T2: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 4, P61165: transmembrane protein 258, P61803: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1, P04843: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1, P04844: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 2, P39656: dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48 kDa subunit, Q9NRP0: oligosaccharyltransferase complex subunit OSTC | - |
Homo sapiens | Q8TCJ2 AND P0C6T2 AND P61165 AND P61803 AND P04843 AND P04844 AND P39656 AND Q9NRP0 | oligosaccharyltransferase B complex. Q8TCJ2: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3B (catalytic subunit). P0C6T2: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 4, P61165: transmembrane protein 258, P61803: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1, P04843: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1, P04844: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 2, P39656: dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48 kDa subunit, Q9NRP0: oligosaccharyltransferase complex subunit OSTC | - |
Saccharomyces cerevisiae | P41543 AND P46964 AND P48439 AND Q99380 AND Q92316 AND P39007 AND P33767 AND Q02795 | P41543: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1, P46964: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 2, P48439: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 3, Q99380: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 4, Q92316: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 5, P39007: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3 (catalytic subunit), P33767: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit WBP1, Q02795: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit SWP1 | - |
Saccharomyces cerevisiae ATCC 204508 | P41543 AND P46964 AND P48439 AND Q99380 AND Q92316 AND P39007 AND P33767 AND Q02795 | P41543: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1, P46964: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 2, P48439: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 3, Q99380: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 4, Q92316: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 5, P39007: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3 (catalytic subunit), P33767: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit WBP1, Q02795: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit SWP1 | - |
Subunits | Comment | Organism |
---|---|---|
More | the eukaryotic oligosaccharyltransferase is a complex of multiple non-identical subunits. The human oligosaccharyltransferase complex is formed with either STT3A or STT3B, two paralogues of Stt3. Human oligosaccharyltransferase complexes, OST-A (with STT3A) and OST-B (containing STT3B) | Homo sapiens |
More | the eukaryotic oligosaccharyltransferase is a complex of multiple non-identical subunits. The Yeast oligosaccharyltransferase enzyme complex contains a single Stt3 subunit | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
OST-A | - |
Homo sapiens |
OST-B | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | defects in N-linked glycosylation results in a class of inherited diseases known as congenital disorders of glycosylation | Homo sapiens |
physiological function | asparagine-linked glycosylation (N-linked glycosylation) is an essential and highly conserved post-translational protein modification. This modification is essential for specific molecular recognition, protein folding, sorting in the endoplasmic reticulum, cell-cell communication, and stability | Saccharomyces cerevisiae |
physiological function | asparagine-linked glycosylation (N-linked glycosylation) is an essential and highly conserved post-translational protein modification. This modification is essential for specific molecular recognition, protein folding, sorting in the endoplasmic reticulum, cell-cell communication, and stability. In humans and other mammals, the oligosaccharyltransferase (OST) complex has diverged into two distinct isoforms known as OST-A and OST-B that perform distinctly different roles in N-linked glycosylation of proteins. OST-A is connected directly to the translocation channel called Sec61 in the ER membrane and scans the newly synthesized unfolded polypeptide chain emerging from the ribosome for glycosylation sites. Therefore, OST-A is responsible for the majority of N-linked glycosylation in mammals. OST-B seems to act in a proofreading role to catch glycosylation sites that OST-A misses for partially folded proteins or proteins that contain disulfide bonds | Homo sapiens |