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Literature summary for 2.4.3.9 extracted from

  • Berselli, P.; Zava, S.; Sottocornola, E.; Milani, S.; Berra, B.; Colombo, I.
    Human GM3 synthase: a new mRNA variant encodes an NH2-terminal extended form of the protein (2006), Biochim. Biophys. Acta, 1759, 348-358.
    View publication on PubMed
Search for more literature for 2.4.3.9

Cloned(Commentary)

Cloned (Comment) Organism
cloning from HL-60 cells, DNA and amino acid sequence determination and analysis, genetic organization of isozymes, mRNA variants differ in the 5'-untranslated region, in vitro transcription and translation using the rabbit reticulocyte lysate system, expression in murine MG1361 cells, a mammary adenocarcinoma cell line Homo sapiens
cloning from placenta, DNA and amino acid sequence determination and analysis, genetic organization of isozymes, mRNA variants differ in the 5'-untranslated region, in vitro transcription and translation using the rabbit reticulocyte lysate system, expression in murine MG1361 cells, a mammary adenocarcinoma cell line Homo sapiens
type 1-4 isozymes, DNA and amino acid sequence determination and analysis, genetic organization of isozymes, mRNA variants differ in the 5'-untranslated region, in vitro transcription and translation using the rabbit reticulocyte lysate system, expression in murine MG1361 cells, a mammary adenocarcinoma cell line Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome membrane and lumen Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CMP-N-acetylneuraminate + lactosylceramide Homo sapiens
-
 CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 5 different isozymes/mRNA variants of different lengths, overview
-
Homo sapiens Q9UNP4 SIAT9; 5 different isozymes/mRNA variants of different lengths, overview
-
Homo sapiens Q9UNP4 ST3GAL5, SIAT9; 5 different isozymes/mRNA variants of different lengths, overview
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain fetal, isozymes type 1-4 Homo sapiens
-
HL-60 cell type 2 isozyme Homo sapiens
-
placenta type 5 isozyme Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + asialoGM1
-
 Homo sapiens CMP + GM1
-
 ?
CMP-N-acetylneuraminate + asialoGM2
-
 Homo sapiens CMP + GM2
-
 ?
CMP-N-acetylneuraminate + galactosylceramide
-
 Homo sapiens CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-ceramide
-
 ?
CMP-N-acetylneuraminate + lactosylceramide
-
 Homo sapiens CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
-
 ?
additional information substrate specificity of isozymes, no activity with GD3 and GM1a as acceptors, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More the isozyme transcripts differ in length and the proteins in molecular weight Homo sapiens

Synonyms

Synonyms Comment Organism
GM3 synthase
-
 Homo sapiens
Sia-T1
-
 Homo sapiens
ST3Gal V
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.4
-
 assay at Homo sapiens