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Literature summary for 2.4.3.8 extracted from
- Sequence requirements for neuropilin-2 recognition by ST8SiaIV and polysialylation of its O-glycans (2016), J. Biol. Chem., 291, 9444-9457 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in COS-1 cells | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q92187 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CMP-N-acetylneuraminate + neuropilin-1 | neuropilin-1 is polysialylated at about 50% of the level of neuropilin-2 but not polysialylated when it lacks its cytoplasmic tail and transmembrane region and is secreted from the cell | Homo sapiens | CMP + ? | - |
? |  |
| CMP-N-acetylneuraminate + neuropilin-2 | neuropilin-2 is polysialylated when either membraneassociated or soluble. The meprin A5 antigen-mu tyrosine phosphatase domain and the O-glycan-containing linker region of neuropilin-2 are necessary and sufficient for its polysialylation | Homo sapiens | CMP + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ST8SiaIV | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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