Literature summary for 2.4.3.8 extracted from

Eby, J.M.; Barse, L.; Henning, S.W.; Rabelink, M.J.; Klarquist, J.; Gilbert, E.R.; Hammer, A.M.; Fernandez, M.F.; Yung, N.; Khan, S.; Miller, H.G.; Kessler, E.R.; Garrett-Mayer, E.; Dilling, D.F.; Hoeben, R.C.; Le Poole, I.C.
alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 can support immune responses toward tumors overexpressing ganglioside D3 in mice (2017), Cancer Immunol. Immunother., 66, 63-75 .

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Application

Application	Comment	Organism
medicine	adenoviral enzyme can slow the growth of ganglioside GD3 expressing tumors in patients	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli TOP10 cells and HEK-293 cells	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CMP-N-acetylneuraminate + ganglioside GM3	Mus musculus	-	CMP + ganglioside GD3	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
natural killer T cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CMP-N-acetylneuraminate + ganglioside GM3	-	Mus musculus	CMP + ganglioside GD3	-	?

Synonyms

Synonyms	Comment	Organism
alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	-	Mus musculus
GD3 synthase	-	Mus musculus
SIAT8	-	Mus musculus

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Release 2023.1 (January 2023)