Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.3.6 extracted from

  • Qi, F.; Isaji, T.; Duan, C.; Yang, J.; Wang, Y.; Fukuda, T.; Gu, J.
    ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the alpha2,3-sialylation of target proteins (2020), FASEB J., 34, 881-897 .
    View publication on PubMed
Search for more literature for 2.4.3.6

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CMP-N-acetyl-beta-neuraminate + beta1-integrin Homo sapiens
-
 CMP + ?
-
 ?
CMP-N-acetyl-beta-neuraminate + epidermal growth factor receptor Homo sapiens
-
 CMP + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q11203
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CW-2 cell
-
 Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
Huh-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
MiaPaCa-2 cell
-
 Homo sapiens
-
PANC-1 cell
-
 Homo sapiens
-
PMF-ko14 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetyl-beta-neuraminate + beta1-integrin
-
 Homo sapiens CMP + ?
-
 ?
CMP-N-acetyl-beta-neuraminate + epidermal growth factor receptor
-
 Homo sapiens CMP + ?
-
 ?

Synonyms

Synonyms Comment Organism
beta-galactoside alpha2,3-sialyltransferase
-
 Homo sapiens
ST3Gal3
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction the phosphorylation levels of AKT and ERK are significantly decreased and the cell growth and colony formation are significantly suppressed in enzyme knockout cells. The expression levels of E-cadherin and claudin-1 are enhanced in enzyme knockout cells Homo sapiens