Application | Comment | Organism |
---|---|---|
medicine | uridine phosphorylase plays an important role in the antineoplastic activity of 5-fluorouracil and in the anabolism of its oral prodrug, capecitabine, through the conversion of 5'-deoxy-5-fluorouridineinto 5-fluorouracil. TNF-alpha efficiently induces UPase gene expression through a NF-kappaB subunit p65-dependent pathway enhancing cell sensitivity to 5'-deoxy-5-fluorouridine. The elucidation of this regulation mechanism may aid in the clinical use of 5-fluorouracil-based chemotherapy | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
EMT6 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
uridine + phosphate | - |
Mus musculus | uracil + alpha-D-ribose 1-phosphate | - |
? |