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Literature summary for 2.4.2.28 extracted from

  • Fernandez-Irigoyen, J.; Santamaria, M.; Sanchez-Quiles, V.; Latasa, M.U.; Santamaria, E.; Munoz, J.; Sanchez Del Pino, M.M.; Valero, M.L.; Prieto, J.; Avila, M.A.; Corrales, F.J.
    Redox regulation of methylthioadenosine phosphorylase in liver cells: molecular mechanism and functional implications (2008), Biochem. J., 411, 457-465.
    View publication on PubMed
Search for more literature for 2.4.2.28

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens
expressed in Escherichia coli BL21(DE3) cells Mus musculus

Protein Variants

Protein Variants Comment Organism
C136S mutant is insensitive to oxidative inhibition Homo sapiens
C136S mutant is insensitive to oxidative inhibition Mus musculus
C223S mutant is insensitive to oxidative inhibition Homo sapiens
C223S mutant is insensitive to oxidative inhibition Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
hydrogen peroxide reversible inactivation, 60% decrease of enzymatic activity at 0.5 mM hydrogen peroxide Homo sapiens
hydrogen peroxide reversible inactivation, 60% decrease of enzymatic activity at 0.5 mM hydrogen peroxide Mus musculus
additional information MTAP is inactivated in the liver of lipopolysaccharide-challenged mice Mus musculus
tert-butyl hydroperoxide 0.01 mM Homo sapiens
tert-butyl hydroperoxide 0.01 mM Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus Q9CQ65
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni2+-Sepharose column chromatography Homo sapiens
Ni2+-Sepharose column chromatography Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
liver
-
 Mus musculus
-
SK-HEP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-methylthioadenosine + phosphate
-
 Homo sapiens adenine + 5-methylthio-D-ribose 1-phosphate
-
 r
5'-methylthioadenosine + phosphate
-
 Mus musculus adenine + 5-methylthio-D-ribose 1-phosphate
-
 r

Synonyms

Synonyms Comment Organism
5'-deoxy-5'-methylthioadenosine:orthophosphate methylthioribosyltransferase
-
 Homo sapiens
5'-deoxy-5'-methylthioadenosine:orthophosphate methylthioribosyltransferase
-
 Mus musculus
5'-methylthioadenosine phosphorylase
-
 Homo sapiens
5'-methylthioadenosine phosphorylase
-
 Mus musculus
MTAP
-
 Homo sapiens
MTAP
-
 Mus musculus