Protein Variants | Comment | Organism |
---|---|---|
K326Q | insensitive to inhibition by GMP, reduced synergistic inhibition | Escherichia coli |
K326Q/P410W | binding of GMP and AMP is abolished resulting in loss of inhibition | Escherichia coli |
P410W | reduced inhibition by AMP, strong synergistic inhibition by AMP and GMP | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | synergistic inhibition by AMP and GMP, binding of GMP to an allosteric i.e. A site and AMP to a proximal catalytic i. e. C site are necessary for synergistic inhibition | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |