Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.12 extracted from

  • Hara, N.; Osago, H.; Hiyoshi, M.; Kobayashi-Miura, M.; Tsuchiya, M.
    Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry (2019), PLoS ONE, 14, e0214000 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.12

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 10 mM used in assay conditions Mus musculus
Mg2+ 10 mM used in assay conditions Rattus norvegicus
Mg2+ 10 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Mus musculus
-
 nicotinamide D-ribonucleotide + diphosphate
-
 ?
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Rattus norvegicus
-
 nicotinamide D-ribonucleotide + diphosphate
-
 ?
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
 nicotinamide D-ribonucleotide + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P43490
-
-
Mus musculus Q99KQ4
-
-
Rattus norvegicus Q80Z29
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
-
 Mus musculus
-
Caco-2 cell
-
 Homo sapiens
-
Fao cell
-
 Rattus norvegicus
-
H9c2 cell
-
 Rattus norvegicus
-
HEK-293 cell
-
 Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Mus musculus nicotinamide D-ribonucleotide + diphosphate
-
 ?
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Rattus norvegicus nicotinamide D-ribonucleotide + diphosphate
-
 ?
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
Nam phosphoribosyltransferase
-
 Mus musculus
Nam phosphoribosyltransferase
-
 Rattus norvegicus
Nam phosphoribosyltransferase
-
 Homo sapiens
Nampt
-
 Mus musculus
Nampt
-
 Rattus norvegicus
Nampt
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism enhanced enzyme expression increases cellular NAD+ concentration no more than 2fold Mus musculus
metabolism enhanced enzyme expression increases cellular NAD+ concentration no more than 2fold Rattus norvegicus
metabolism enhanced enzyme expression increases cellular NAD+ concentration no more than 2fold Homo sapiens