BRENDA - Enzyme Database
show all sequences of 2.4.2.10

Orotate phosphoribosyltransferase levels measured by a newly established enzyme-linked immunosorbent assay in gastric carcinoma

Sakurai, Y.; Sakamoto, K.; Sugimoto, Y.; Yoshida, I.; Masui, T.; Tonomura, S.; Inaba, K.; Shoji, M.; Nakamura, Y.; Uyama, I.; Komori, Y.; Ochiai, M.; Matsuura, S.; Tanaka, H.; Oka, T.; Fukushima, M.; Cancer Sci. 97, 492-498 (2006)

Data extracted from this reference:

Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
the enzyme is involved in degradation of 5-fluorouracil being the key enzyme related to the first-step activation process of 5-fluorouracil, and possibly predicts chemosensitivity to 5-fluorouracil, overview
5-fluorouridine 5'-phosphate + diphosphate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
cholangioma cell
-
Homo sapiens
-
colonic cancer cell
-
Homo sapiens
-
gastric carcinoma cell
-
Homo sapiens
-
lung cancer cell
-
Homo sapiens
-
prostate cancer cell
-
Homo sapiens
-
uterine cancer cell
-
Homo sapiens
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
ELISA assay method development and evaluation for enzyme detection and quantification in cancer tissue, overview
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
-
672923
Homo sapiens
5-fluorouridine 5'-phosphate + diphosphate
-
-
-
?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
the enzyme is involved in degradation of 5-fluorouracil being the key enzyme related to the first-step activation process of 5-fluorouracil, and possibly predicts chemosensitivity to 5-fluorouracil, overview
672923
Homo sapiens
5-fluorouridine 5'-phosphate + diphosphate
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Homo sapiens
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
the enzyme is involved in degradation of 5-fluorouracil being the key enzyme related to the first-step activation process of 5-fluorouracil, and possibly predicts chemosensitivity to 5-fluorouracil, overview
5-fluorouridine 5'-phosphate + diphosphate
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
cholangioma cell
-
Homo sapiens
-
colonic cancer cell
-
Homo sapiens
-
gastric carcinoma cell
-
Homo sapiens
-
lung cancer cell
-
Homo sapiens
-
prostate cancer cell
-
Homo sapiens
-
uterine cancer cell
-
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
ELISA assay method development and evaluation for enzyme detection and quantification in cancer tissue, overview
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
-
672923
Homo sapiens
5-fluorouridine 5'-phosphate + diphosphate
-
-
-
?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
the enzyme is involved in degradation of 5-fluorouracil being the key enzyme related to the first-step activation process of 5-fluorouracil, and possibly predicts chemosensitivity to 5-fluorouracil, overview
672923
Homo sapiens
5-fluorouridine 5'-phosphate + diphosphate
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Homo sapiens
Other publictions for EC 2.4.2.10
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
748831
Paojinda
Bifunctional activity of fuse ...
Plasmodium falciparum
Parasitol. Int.
67
79-84
2018
-
-
1
-
1
-
1
7
-
-
1
1
-
3
-
-
1
-
-
-
-
1
1
2
-
-
-
6
-
-
-
-
6
-
-
-
-
1
-
-
1
-
-
1
6
7
-
-
1
1
-
-
-
1
-
-
-
1
1
2
-
-
-
6
-
-
-
-
-
1
1
-
6
6
735519
Qi
Orotate phosphoribosyl transfe ...
Magnaporthe oryzae, Magnaporthe oryzae ATCC MYA-4617
Appl. Microbiol. Biotechnol.
100
3655-3666
2016
-
-
1
-
-
-
-
-
-
-
-
2
-
8
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
736180
Surekha
Investigation of vital pathoge ...
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Gene
583
102-111
2016
-
-
-
-
-
-
-
-
-
-
-
2
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735403
Kumar
Structure of Plasmodium falcip ...
Plasmodium falciparum
Acta Crystallogr. Sect. F
71
600-608
2015
-
-
1
1
-
-
-
-
-
1
-
1
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735748
Hozumi
Orotate phosphoribosyltransfer ...
Homo sapiens
Biomed. Res.
36
403-409
2015
-
-
1
-
-
-
-
-
1
-
1
1
-
1
-
-
1
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
1
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735941
Subrahmanyeswara Rao
-
An organism-independent unifie ...
Mycobacterium tuberculosis, Plasmodium falciparum, Saccharomyces cerevisiae, Salmonella enterica subsp. enterica serovar Typhimurium
Chem. Eng. Sci.
128
109-118
2015
-
-
-
-
-
-
-
-
-
-
-
4
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
721790
Hansen
Backbone 1H, 13C, 15N NMR assi ...
Saccharomyces cerevisiae
Biomol. NMR Assign.
8
103-108
2014
-
-
1
-
-
-
-
-
-
1
1
-
-
3
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735577
Imprasittichail
A unique insertion of low comp ...
Plasmodium falciparum
Asian Pac. J. Trop. Med.
7
184-192
2014
-
-
1
-
-
-
-
-
-
-
2
1
-
4
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
736435
Zhang
Transition state analogues of ...
Homo sapiens, Plasmodium falciparum
J. Biol. Chem.
288
34746-34754
2013
-
-
2
-
-
-
40
-
-
-
-
2
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
40
-
-
-
-
2
-
-
-
-
-
40
40
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
721228
Takashima
Crystallization and preliminar ...
Plasmodium falciparum
Acta Crystallogr. Sect. F
68
244-246
2012
-
-
1
1
-
-
-
-
-
1
-
-
-
4
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722193
Breda
Pyrimidin-2(1H)-ones based inh ...
Mycobacterium tuberculosis
Eur. J. Med. Chem.
54
113-122
2012
-
-
1
-
-
-
4
-
-
1
-
-
-
5
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
8
-
-
-
-
1
-
-
-
-
-
4
8
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723161
Breda
Molecular, kinetic and thermod ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Mol. Biosyst.
8
572-586
2012
-
-
1
-
-
-
2
6
-
1
3
-
-
4
-
-
1
-
-
-
1
1
4
1
-
-
-
4
-
-
-
-
8
-
-
-
-
1
-
-
-
-
-
2
8
6
-
1
3
-
-
-
-
1
-
-
1
1
4
1
-
-
-
4
-
-
-
-
-
-
-
-
6
6
721644
Zhang
Ground-state destabilization i ...
Homo sapiens, Plasmodium falciparum
Biochemistry
50
4813-4818
2011
-
-
2
-
-
-
2
4
-
-
-
-
-
2
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
4
-
-
-
-
2
-
-
-
-
-
2
4
4
-
-
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
721192
Liu
Structure of orotate phosphori ...
Streptococcus mutans
Acta Crystallogr. Sect. F
66
498-502
2010
-
-
1
1
-
-
-
-
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722447
Zhang
Leaving group activation and p ...
Plasmodium falciparum
J. Am. Chem. Soc.
132
17023-17031
2010
-
-
1
-
-
-
-
1
-
1
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722451
Zhang
Pyrophosphate interactions at ...
Homo sapiens, Plasmodium falciparum
J. Am. Chem. Soc.
132
8787-8794
2010
-
-
2
-
-
-
-
4
-
2
-
-
-
2
-
-
2
-
-
-
-
-
4
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
4
-
2
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
2
-
-
-
-
-
-
-
-
2
2
704190
Zhang
Transition states of Plasmodiu ...
Homo sapiens, Plasmodium falciparum
J. Am. Chem. Soc.
131
4685-4694
2009
-
-
2
-
-
-
4
8
-
2
-
-
-
4
-
-
2
-
-
-
-
-
6
-
-
-
-
8
-
-
-
-
4
-
-
-
-
2
-
-
-
-
-
4
4
8
-
2
-
-
-
-
-
2
-
-
-
-
6
-
-
-
-
8
-
-
-
-
-
-
-
-
4
4
706025
Tanaka
Overexpression of orotate phos ...
Homo sapiens
Oncol. Rep.
21
33-37
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
684221
Ogiuchi
Thymidylate synthase, thymidin ...
Homo sapiens
Acta Histochem. Cytochem.
41
39-46
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685814
Ishikawa
Clinical implications of thymi ...
Homo sapiens
BMC Cancer
8
188
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706021
Sanada
Expression of orotate phosphor ...
Homo sapiens
Oncol. Rep.
20
1005-1011
2008
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
706023
Tsutani
Decreased orotate phosphoribos ...
Homo sapiens
Oncol. Rep.
20
1545-1551
2008
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
673097
Matsusaka
Upregulation of enzymes metabo ...
Homo sapiens
Chemotherapy
53
36-41
2007
-
-
-
-
-
-
-
-
-
1
-
1
-
3
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
676296
Sanada
Expression of orotate phosphor ...
Homo sapiens
Pathol. Oncol. Res.
13
105-113
2007
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
8
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
8
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677169
Tokunaga
Clinical role of orotate phosp ...
Homo sapiens
Surgery
141
346-353
2007
-
1
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684875
Sakamoto
Orotate phosphoribosyltransfer ...
Homo sapiens
Biochem. Biophys. Res. Commun.
363
216-222
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685117
Gonzalez-Segura
Ternary complex formation and ...
Saccharomyces cerevisiae
Biochemistry
46
14075-14086
2007
-
-
1
1
3
-
-
7
-
1
-
-
-
3
-
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
3
-
-
-
-
7
-
1
-
-
-
-
-
1
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685927
Kai
Quantitative double-fluorescen ...
Homo sapiens
Cancer Lett.
258
45-54
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686922
Sakurai
Levels and expressions of orot ...
Homo sapiens
Gastric Cancer
10
234-240
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687155
Miyake
Role of thymidine phosphorylas ...
Homo sapiens
Int. J. Clin. Oncol.
12
111-119
2007
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687400
Wang
Orotate phosphoribosyltransfer ...
Corynebacterium ammoniagenes
J. Bacteriol.
189
9030-9036
2007
-
-
1
-
-
-
-
4
-
1
2
-
-
5
-
-
1
-
-
-
4
1
1
1
-
-
1
-
2
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
4
-
1
2
-
-
-
-
1
-
-
4
1
1
1
-
-
1
-
2
-
-
1
-
-
-
-
-
-
689294
Nio
Expression of orotate phosphor ...
Homo sapiens
Oncol. Rep.
18
59-64
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672162
McClard
Half-of-sites binding of oroti ...
Saccharomyces cerevisiae
Biochemistry
45
5330-5342
2006
-
-
-
-
-
-
-
1
-
1
-
1
-
2
-
-
-
1
-
-
-
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
672923
Sakurai
Orotate phosphoribosyltransfer ...
Homo sapiens
Cancer Sci.
97
492-498
2006
-
-
-
-
-
-
-
-
-
1
-
1
-
3
-
-
-
-
-
6
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
6
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
673120
Ichikawa
Orotate phosphoribosyltransfer ...
Homo sapiens
Clin. Cancer Res.
12
3928-3934
2006
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674045
Ochiai
Prognostic impact of orotate p ...
Homo sapiens
Int. J. Cancer
118
3084-3088
2006
-
1
-
-
-
-
-
-
-
1
-
2
-
2
-
-
-
-
-
2
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
676267
Oeda
The expression profiles of oro ...
Homo sapiens
Oncol. Rep.
16
1165-1172
2006
-
1
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676270
Taomoto
Overexpression of the orotate ...
Homo sapiens
Oncology
70
458-464
2006
-
-
1
-
-
-
-
-
-
-
1
1
-
2
-
-
-
-
-
3
4
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
3
4
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
658105
Krungkrai
A novel enzyme complex of orot ...
Plasmodium falciparum
Biochemistry
44
1643-1652
2005
-
-
1
-
-
2
-
6
-
-
4
-
-
7
-
-
-
-
-
-
-
-
1
2
-
-
-
3
-
1
-
-
-
-
-
-
-
1
-
-
-
2
-
-
-
6
-
-
4
-
-
-
-
-
-
-
-
-
1
2
-
-
-
3
-
1
-
-
-
-
-
-
-
-
658935
Sakamoto
Preparation of anti-orotate ph ...
Homo sapiens
Int. J. Mol. Med.
16
245-249
2005
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674056
Kawai
Correlation between expression ...
Homo sapiens
Int. J. Gastrointest. Cancer
35
197-203
2005
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657769
Krungkrai
Orotate phosphoribosyltransfer ...
Plasmodium falciparum
Biochem. Biophys. Res. Commun.
318
1012-1018
2004
-
-
-
-
-
-
-
2
-
-
3
-
-
3
-
-
1
-
-
-
1
-
1
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
1
-
-
1
-
1
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
658308
Takeno
Cloning and sequencing of the ...
Mortierella alpina, Mortierella alpina 1S-4
Biosci. Biotechnol. Biochem.
68
277-285
2004
-
-
1
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658375
Mizutani
Prognostic significance of oro ...
Homo sapiens
Cancer
100
723-731
2004
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659903
Krungkrai
Human malaria parasite orotate ...
Plasmodium falciparum
Mol. Biochem. Parasitol.
134
245-255
2004
-
-
1
-
-
1
12
5
-
-
3
-
-
5
-
-
1
1
-
-
-
-
2
1
-
-
-
5
-
-
-
-
15
1
-
-
-
1
-
-
-
1
-
12
15
5
-
-
3
-
-
-
-
1
-
-
-
-
2
1
-
-
-
5
-
-
-
1
-
-
-
-
-
-
659947
Kim
Crystallization and preliminar ...
Helicobacter pylori
Mol. Cells
15
361-363
2003
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678999
Santiago
Control of pyrimidine formatio ...
Pseudomonas putida
Can. J. Microbiol.
48
1076-1081
2002
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
489731
Krungkrai
A nonradioactive high-performa ...
Homo sapiens, Mus musculus
Anal. Biochem.
299
162-168
2001
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
489727
Javaid
Pyrimidine nucleobase ligands ...
Toxoplasma gondii
Biochem. Pharmacol.
58
1457-1466
1999
-
-
-
-
-
-
4
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
489729
Hamana
Effects of C-terminal deletion ...
Thermus thermophilus
J. Biochem.
125
109-114
1999
-
-
-
-
1
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
489734
Witte
Cloning, overproduction, and p ...
Saccharomyces cerevisiae
Arch. Biochem. Biophys.
361
106-112
1999
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
489733
Bayles
Sequence and phylogenetic anal ...
Rhizobium leguminosarum
Gene
195
329-336
1997
-
-
1
-
-
-
1
1
-
-
1
-
-
5
-
-
1
-
-
-
1
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
1
-
-
1
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
4187
Yablonski
Intrinsic activity and stabili ...
Homo sapiens
J. Biol. Chem.
271
10704-10708
1996
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
489728
Tao
Transition state structure of ...
Salmonella enterica subsp. enterica serovar Typhimurium
Biochemistry
35
14-21
1996
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
489735
Henriksen
A flexible loop at the dimer i ...
Escherichia coli
Biochemistry
35
3803-3809
1996
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
489726
Ozturk
Structure and Function of Salm ...
Salmonella enterica subsp. enterica serovar Typhimurium
Biochemistry
34
10764-10770
1995
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
489730
Bunnak
Orotate phosphoribosyltransfer ...
Thermus thermophilus
J. Biochem.
118
1261-1267
1995
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
1
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
489736
Scapin
Crystal structure of orotate p ...
Salmonella enterica subsp. enterica serovar Typhimurium
Biochemistry
33
1287-1294
1994
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
489714
Bhatia
The role of divalent magnesium ...
Salmonella enterica subsp. enterica serovar Typhimurium
Arch. Biochem. Biophys.
303
321-325
1993
-
-
-
-
-
-
-
4
-
2
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
2
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
489724
Scapin
Primary structure and crystall ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Mol. Biol.
230
1304-1308
1993
-
-
-
1
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
489723
Bhatia
Kinetic mechanism of orotate p ...
Salmonella enterica subsp. enterica serovar Typhimurium
Biochemistry
29
10480-10487
1990
-
-
1
-
-
-
4
3
-
-
1
1
-
3
-
-
1
1
-
-
1
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
3
-
-
1
1
-
-
-
1
-
-
1
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
4180
Floyd
Isolation and characterization ...
Mus musculus
J. Biol. Chem.
260
9443-9451
1985
-
-
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
489719
Shimosaka
Purification and properties of ...
Escherichia coli
J. Biochem.
98
1689-1697
1985
-
-
-
-
-
-
11
8
-
5
2
1
-
2
-
-
1
-
-
-
3
-
2
1
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
11
-
8
-
5
2
1
-
-
-
1
-
-
3
-
2
1
-
-
-
-
2
2
-
-
-
-
-
-
-
-
489721
Rathod
Orotidylate-metabolizing enzym ...
Homo sapiens, Plasmodium falciparum, Plasmodium falciparum FCB
J. Biol. Chem.
258
2852-2855
1983
-
-
-
-
-
-
3
-
2
-
-
3
-
6
-
-
-
-
-
1
-
1
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
-
-
3
-
-
-
-
-
1
-
1
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
489720
Dodin
A rapid purification by affini ...
Escherichia coli
FEBS Lett.
134
20-24
1981
-
-
-
-
-
-
-
-
1
-
1
-
-
2
-
-
1
-
-
-
1
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
-
1
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
489713
McClard
Isolation and initial characte ...
Mus musculus
Biochemistry
19
4699-4706
1980
-
-
-
-
-
1
-
-
-
-
2
-
-
1
-
-
1
-
-
1
1
1
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
1
-
1
1
1
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
489716
Victor
Divalent metal ion activation ...
Saccharomyces cerevisiae
Biochemistry
18
3597-3604
1979
-
-
-
-
-
-
1
-
-
4
-
-
-
2
-
-
-
1
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
4
-
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
489718
Victor
Studies of the kinetic mechani ...
Saccharomyces cerevisiae
J. Biol. Chem.
254
2647-2655
1979
-
-
-
-
-
-
12
6
-
1
2
-
-
2
-
-
-
1
-
-
2
-
4
1
1
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
12
4
6
-
1
2
-
-
-
-
-
-
-
2
-
4
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
489712
Jones
Orotate phosphoribosyltransfer ...
Mus musculus
Methods Enzymol.
51
155-167
1978
-
-
-
-
-
5
28
3
-
1
-
-
-
1
-
-
1
-
-
1
1
2
1
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
5
-
28
-
3
-
1
-
-
-
-
-
1
-
1
1
2
1
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
489715
Yoshimoto
Orotate phosphoribosyltransfer ...
Saccharomyces cerevisiae
Methods Enzymol.
51
69-74
1978
-
-
-
-
-
-
2
5
-
-
1
-
-
1
-
-
1
-
-
-
1
2
1
-
1
-
-
-
1
-
1
-
2
-
-
-
-
-
-
-
-
-
-
2
2
5
-
-
1
-
-
-
-
1
-
-
1
2
1
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
489717
Reyes
Purification of orotate phosph ...
Saccharomyces cerevisiae
Anal. Biochem.
88
522-531
1978
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
489725
Ashihara
-
Orotate Phosphoribosyltransfer ...
Vigna mungo
Z. Pflanzenphysiol.
87
225-241
1978
1
-
-
-
-
-
4
2
2
1
-
-
-
1
-
-
1
-
-
1
1
-
1
-
1
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
4
-
2
2
1
-
-
-
-
-
1
-
1
1
-
1
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-