Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | 2 mM, complete inhibition | Paeniclostridium sordellii |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | stimulation, maximum activity at 1 mM | Paeniclostridium sordellii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Paeniclostridium sordellii | Q46342 | cytotoxin L | - |
Paeniclostridium sordellii 6018 | Q46342 | cytotoxin L | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | lethal toxin from Clostridium sordellii is a glucosyltransferase, which uses UDP-glucose as cosubstrate to modify low molecular mass GTPases. Lethal toxin selectively modifies Rac and Ras. In Rac, acceptor amino acid is residue threonine 35. No substrates: Rho, Cdc42, Rab, Arf | Paeniclostridium sordellii | ? | - |
? | |
additional information | lethal toxin from Clostridium sordellii is a glucosyltransferase, which uses UDP-glucose as cosubstrate to modify low molecular mass GTPases. Lethal toxin selectively modifies Rac and Ras. In Rac, acceptor amino acid is residue threonine 35. No substrates: Rho, Cdc42, Rab, Arf | Paeniclostridium sordellii 6018 | ? | - |
? | |
UDP-alpha-D-glucose + H-Ras | Ras is the exclusive substrate of the Ras subfamily of GTPases. Ras is a better substrate in the GTDP-bound form than in the GTP-bound form | Paeniclostridium sordellii | UDP + D-glucosyl-H-Ras | - |
? | |
UDP-alpha-D-glucose + H-Ras | Ras is the exclusive substrate of the Ras subfamily of GTPases. Ras is a better substrate in the GTDP-bound form than in the GTP-bound form | Paeniclostridium sordellii 6018 | UDP + D-glucosyl-H-Ras | - |
? | |
UDP-alpha-D-glucose + Rac1 | Rac is the exclusive substrate of the Rho subfamily of GTPases. Rac is a better substrate in the GTDP-bound form than in the GTP-bound form | Paeniclostridium sordellii | UDP + D-glucosyl-Rac1 | - |
? | |
UDP-alpha-D-glucose + Rac1 | Rac is the exclusive substrate of the Rho subfamily of GTPases. Rac is a better substrate in the GTDP-bound form than in the GTP-bound form | Paeniclostridium sordellii 6018 | UDP + D-glucosyl-Rac1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lethal toxin | - |
Paeniclostridium sordellii |
General Information | Comment | Organism |
---|---|---|
physiological function | glucosylation of Ras by lethal toxin results in inhibition of the epidermal growth factor-stimulated p42/p44 MAP-kinase signal pathway | Paeniclostridium sordellii |