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Literature summary for 2.4.1.87 extracted from

  • Gao, H.; Zhao, C.; Xiang, X.; Li, Y.; Zhao, Y.; Li, Z.; Pan, D.; Dai, Y.; Hara, H.; Cooper, D.K.; Cai, Z.; Mou, L.
    Production of alpha1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning (2017), J. Reprod. Dev., 63, 17-26 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine development of alpha-1,3-galactosyltransferase (GGTA1) and cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) double-knockout piglets as donor animals for xenotransplantation. Compared to cells from GGTA1-knockout pigs, human antibody binding and antibody-mediated complement-dependent cytotoxicity are significantly reduced in cells from GGTA1/CMAH double-knockout pigs Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa P50127
-
-

Synonyms

Synonyms Comment Organism
GGTA1
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 Sus scrofa