Application | Comment | Organism |
---|---|---|
medicine | GCS expression is significantly down-regulated in Alzheimer brain | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-threo-2-palmitoylamino-3-pyrrolidino-1-propanol | - |
Homo sapiens | |
D-threo-2-palmitoylamino-3-pyrrolidino-1-propanol | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebellar cortex | GCS expression is significantly decreased in cortex of Alzheimer disease patients | Homo sapiens | - |
granule cell | cerebellar granule cells are treated with GCS inhibitor D-threo-2-palmitoylamino-3-pyrrolidino-1-propanol which induces an increase in log-chain ceramides, loss of viability and dramatic changes in neuron/neurite morphology | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
GCS | - |
Homo sapiens |
GCS | - |
Rattus norvegicus |
glucosylceramide synthase | - |
Homo sapiens |
glucosylceramide synthase | - |
Rattus norvegicus |