Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dioleoyl phosphatidylcholine | or other exogenous phospholipid, required for activity | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi membrane | - |
Rattus norvegicus | 139 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + N-acylsphingosine | Rattus norvegicus | initial key enzyme in glycosphingolipid biosynthesis | UDP + D-glucosyl-N-acylsphingosine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0436 | - |
purified enzyme | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CDP-glucose + N-acylsphingosine | i.e. ceramide | Rattus norvegicus | CDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
TDP-glucose + N-acylsphingosine | i.e. ceramide | Rattus norvegicus | TDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphinganine | stereospecific and dependent on nature and chain length of N-acylsphinganine substrate | Rattus norvegicus | UDP + D-glucosyl-N-acylsphingosine | - |
? | |
UDP-glucose + N-acylsphingosine | acceptor substrate specificity, overview | Rattus norvegicus | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | i.e. ceramide | Rattus norvegicus | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | stereospecific and dependent on nature and chain length of N-acylsphingosine substrate | Rattus norvegicus | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | UDP-glucose is the preferred donor substrate | Rattus norvegicus | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | initial key enzyme in glycosphingolipid biosynthesis | Rattus norvegicus | UDP + D-glucosyl-N-acylsphingosine | - |
? | |
UDP-glucose + N-[7-(4-nitrobenzo-2-oxa-1,3-diazole)]-6-aminocaproyl-D-erythro-sphingosine | synthetic fluorescent ceramide substrate analogue for fluorescence enzyme assay | Rattus norvegicus | UDP + D-glucosyl-N-[7-(4-nitrobenzo-2-oxa-1,3-diazole)]-6-aminocaproyl-D-erythro-sphingosine | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 60000-66000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
GCS | - |
Rattus norvegicus |
UDP-Glc:ceramide glucosyltransferase | - |
Rattus norvegicus |