Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Detergents | e.g. 0.5% Triton X-100 or 0.5% sodium deoxycholate; inhibition of enzyme due to permeabilization of microsomal membrane | Rattus norvegicus | |
Phospholipase A | treatment of microsomes results in loss of enzyme activity | Rattus norvegicus | |
Phospholipase C | treatment of microsomes results in loss of enzyme activity | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Rattus norvegicus | 16020 | - |
microsome | associated with membranes, structural integrity of the microsomal membranes is essential for activity | Rattus norvegicus | - |
- |
additional information | enzyme is not associated with synaptosomes and myelin | Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + N-acylsphingosine | Rattus norvegicus | catalyzes the first step during the sequential addition of carbohydrate moieties for ganglioside biosynthesis | UDP + D-glucosyl-N-acylsphingosine | - |
? | |
UDP-glucose + N-acylsphingosine | Rattus norvegicus Sprague-Dawley | catalyzes the first step during the sequential addition of carbohydrate moieties for ganglioside biosynthesis | UDP + D-glucosyl-N-acylsphingosine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley | - |
Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + dihydrosphingosine | dihydrosphingosine is no substrate | Rattus norvegicus | UDP + D-glucosyl-dihydrosphingosine | - |
? | |
UDP-glucose + dihydrosphingosine | dihydrosphingosine is no substrate | Rattus norvegicus Sprague-Dawley | UDP + D-glucosyl-dihydrosphingosine | - |
? | |
UDP-glucose + N-acylsphingosine | i.e. ceramide | Rattus norvegicus | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | catalyzes the first step during the sequential addition of carbohydrate moieties for ganglioside biosynthesis | Rattus norvegicus | UDP + D-glucosyl-N-acylsphingosine | - |
? | |
UDP-glucose + N-acylsphingosine | i.e. ceramide | Rattus norvegicus Sprague-Dawley | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
UDP-glucose + N-acylsphingosine | catalyzes the first step during the sequential addition of carbohydrate moieties for ganglioside biosynthesis | Rattus norvegicus Sprague-Dawley | UDP + D-glucosyl-N-acylsphingosine | - |
? |