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Literature summary for 2.4.1.66 extracted from

  • Wang, C.; Ristiluoma, M.M.; Salo, A.M.; Eskelinen, S.; Myllylae, R.
    Lysyl hydroxylase 3 is secreted from cells by two pathways (2012), J. Cell. Physiol., 227, 668-675.
    View publication on PubMed
Search for more literature for 2.4.1.66

Cloned(Commentary)

Cloned (Comment) Organism
expressed in MDCK, COS-7 and HT-1080 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
D187A/D189A/D190A/D191A the mutant shows unreduced lysyl hydroxylase 3 activity Homo sapiens
D669A the mutant shows no lysyl hydroxylase 3 activity Homo sapiens
N23S lysyl hydroxylase 3 activity is reduced by nearly 50% Homo sapiens
R729A the mutant shows no lysyl hydroxylase 3 activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-
endoplasmic reticulum secretion of the enzyme from the endoplasmic reticulum to the extracellular space occurs via two secretory pathways, which generate two glycoforms. Enzyme molecules found in the cell medium are secreted through the Golgi complex, and the secretion is dependent on lysyl hydroxylase 3 glycosyltransferase activity. Enzyme found on the cell surface bypasses the Golgi complex Homo sapiens 5783
-
extracellular
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information lysyl hydroxylase 3 is a post-translational modification enzyme with lysyl hydroxylase collagen galactosyltransferase, and glucosyltransferase activities Homo sapiens ?
-
 ?
UDP-glucose + calf skin gelatin
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
LH3
-
 Homo sapiens
lysyl hydroxylase
-
 Homo sapiens