Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
alpha(1,3/4)-FUT | - |
Mus musculus |
alpha-1,3-fucosyltransferase | - |
Mus musculus |
FUT4 | isoform | Mus musculus |
FUT7 | isoform | Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | mice lacking both isoforms FUT4 and FUT7 have a shorter time to occlusive thrombus formation in the injured carotid artery and a higher mortality due to collagen/epinephrine-induced pulmonary thromboemboli. FUT4-, but not FUT7, -deficient mice have increased pulmonary thromboembolism-induced mortality and decreased thromboemboli dissolution in vivo | Mus musculus |
metabolism | isoforms FUT4 and FUT7 are required for the synthesis of functional selectin-type leukocyte adhesion molecule ligands | Mus musculus |
physiological function | isoform FUT4 and FUT7 activity regulates thrombosis in a P-selectine and P-selectin glycoprotein ligand-1-independent manner. Isoform FUT4 activity is important for thrombolysis | Mus musculus |