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Literature summary for 2.4.1.50 extracted from

  • Baumann, S.; Hennet, T.
    Collagen accumulation in osteosarcoma cells lacking GLT25D1 collagen galactosyltransferase (2016), J. Biol. Chem., 291, 18514-18524 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.50

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IYK4 isoform GLT25D2
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Homo sapiens Q8NBJ5 isoform GLT25D1
-

Source Tissue

Source Tissue Comment Organism Textmining
MG-63 cell
-
 Homo sapiens
-
SAOS-2 cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
COLGALT1
-
 Homo sapiens
COLGALT2
-
 Homo sapiens
GLT25D1
-
 Homo sapiens
GLT25D2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function loss of GLT25D1 leads to increased expression and intracellular accumulation of collagen type I. Inactivation of the GLT25D1 gene results in a compensatory induction of isoform GLT25D2 expression. Loss of GLT25D1 decreases collagen glycosylation by up to 60% but does not alter collagen folding and thermal stability. Cells harboring individually inactivated GLT25D1 and GLT25D2 genes can be recovered and maintained in culture, cell clones with simultaneously inactive GLT25D1 and GLT25D2 genes cannot be grown Homo sapiens
physiological function loss of GLT25D2 has no effect on collagen secretion. Inactivation of the GLT25D1 gene results in a compensatory induction of isoform GLT25D2 expression. Cells harboring individually inactivated GLT25D1 and GLT25D2 genes can be recovered and maintained in culture, cell clones with simultaneously inactive GLT25D1 and GLT25D2 genes cannot be grown Homo sapiens