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Literature summary for 2.4.1.41 extracted from

  • Xu, Y.; Pang, W.; Lu, J.; Shan, A.; Zhang, Y.
    Polypeptide N-acetylgalactosaminyltransferase 13 contributes to neurogenesis via stabilizing the mucin-type O-glycoprotein podoplanin (2016), J. Biol. Chem., 291, 23477-23488 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.41

Organism

Organism UniProt Comment Textmining
Mus musculus Q8CF93
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-

Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Mus musculus
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P-19 cell
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + mucin-type O-glycoprotein podoplanin
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 Mus musculus UDP + N-acetyl-alpha-D-galactosaminyl-mucin-type O-glycoprotein podoplanin
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 ?

Synonyms

Synonyms Comment Organism
GalNAc-T13
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 Mus musculus
Galnt13
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 Mus musculus

Expression

Organism Comment Expression
Mus musculus expression of GalNAc-T13 is dramatically upregulated during early neurogenesis in mouse embryonic brains up

General Information

General Information Comment Organism
physiological function knockout of GalNAc-T13 in P19 cells suppresses not only neural induction but also neuronal differentiation. The effects are at least partly mediated by the mucin-type O-glycoprotein podoplanin. Knockdown of podoplanin leads to a similar inhibition of neuronal differentiation and podoplanin is significantly reduced at the posttranscriptional level after GalNAc-T13 knockout. Podoplanin acts as a substrate of GalNAc-T13 and the ppGalNAc-T13-mediated O-glycosylation on podoplanin is important for its stability Mus musculus