Cloned (Comment) | Organism |
---|---|
expressed in Sf9 insect cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K521Q | the mutation enhances the carbohydrate specificity of lectin domain for alpha-GalNAc and results in reduced enzyme activity compared to the wild type enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
benzyl N-acetyl-alpha-D-galactosamine | - |
Homo sapiens | |
additional information | not inhibited by by D-glucose or UDP-N-acetyl-alpha-D-galactosamine | Homo sapiens | |
N-acetyl-alpha-D-galactosamine | the acetylated enzyme is strongly inhibited by N-acetyl-alpha-D-galactosamine | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-alpha-D-galactosamine + polypeptide | Homo sapiens | - |
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Co2+-charged resin column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-alpha-D-galactosamine + polypeptide | - |
Homo sapiens | UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
polypeptide GalNAc-transferase-2 | - |
Homo sapiens |
ppGalNAc-T2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
10 | - |
acetylated wild type enzyme, at pH 7.4 and 37°C | Homo sapiens | benzyl N-acetyl-alpha-D-galactosamine | |
15 | - |
mutant enzyme K521Q, at pH 7.4 and 37°C | Homo sapiens | N-acetyl-alpha-D-galactosamine | |
20 | - |
acetylated wild type enzyme, at pH 7.4 and 37°C | Homo sapiens | N-acetyl-alpha-D-galactosamine |