Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces venezuelae | Q9ZGH7 | enzyme catalyzes reaction of EC 2.4.1.277 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dTDP-D-desosamine + 3-alpha-L-mycarosylerythronolide B | - |
Streptomyces venezuelae | dTDP + erythromycin D | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DesVII | - |
Streptomyces venezuelae |
General Information | Comment | Organism |
---|---|---|
physiological function | coexpression of glycosyltransferase DesVII and its auxiliary partner DesVIII in a Saccharopolyspora erythraea EryBV deletion mutant leads to an increased erythromycin A yield by 15% in comparison to Saccharopolyspora erythraea wild-type. DesVII/DesVIII replaced EryCIII to upload D-desosamine to C5 position of 3-O-mycarosyl erythronolide B and also in vivo attache L-mycarose, not D-desosamine to C3 position of erythronolide B with a higher activity than EryBV. Expression of DesVII in EryCIII and EryBV-CIII mutant strains partially restores the erythromycin A production, however, no erythromycin A is detected while DesVII is expressed in the EryBV mutant strain | Streptomyces venezuelae |