Any feedback?
Literature summary for 2.4.1.223 extracted from
- Structural and biophysical characterization of human EXTL3 domain organization, glycosylation, and solution structure (2018), Biochemistry, 57, 1166-1177 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| human lumenal N-glycosylated EXTL3 (EXTL3DELTAN) is cloned, expressed in human embryonic kidney cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | human EXTL3 is inserted into the Golgi apparatus membrane by an N-terminal transmembrane helix of 20 residues, followed by an unstructured protein segment of about 18 residues, rich in charged amino acids, and then around 80 residues of coiled-coil structure that may play a role in positioning and/or orienting the following catalytic domains on the Golgi membrane | Homo sapiens | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O43909 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EXTL3 | - |
Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 59 | - |
high temperatures (about 59°C) are required to denaturation | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the EXTL3 enzyme mainly works as an initiator in heparan sulfate biosynthesis | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
