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Literature summary for 2.4.1.18 extracted from

  • Rashid, A.M.; Batey, S.F.; Syson, K.; Koliwer-Brandl, H.; Miah, F.; Barclay, J.E.; Findlay, K.C.; Nartowski, K.P.; Khimyak, Y.Z.; Kalscheuer, R.; Bornemann, S.
    Assembly of alpha-glucan by GlgE and GlgB in Mycobacteria and Streptomycetes (2016), Biochemistry, 55, 3270-3284 .
    View publication on PubMed
Search for more literature for 2.4.1.18

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WN45
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Mycobacterium tuberculosis ATCC 25618 P9WN45
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Streptomyces coelicolor
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Streptomyces coelicolor ATCC BAA-471
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Synonyms

Synonyms Comment Organism
GlgB
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 Streptomyces coelicolor
GlgB
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 Mycobacterium tuberculosis

General Information

General Information Comment Organism
metabolism the following assembly mechanism is proposed. Polymer synthesis starts with GlgE and its donor substrate, alpha-maltose 1-phosphate, yielding a linear oligomer with a degree of polymerization (of about 16) sufficient for GlgB to introduce a branch. Branching involves strictly intrachain transfer to generate a C chain (the only constituent chain to retain its reducing end), which now bears an A chain (a nonreducing end terminal branch that does not itself bear a branch). GlgE preferentially extends A chains allowing GlgB to act iteratively to generate new A chains emanating from B chains (nonterminal branches that themselves bear a branch). Although extension and branching occur primarily with A chains, the other chain types are sometimes extended and branched such that some B chains (and possibly C chains) bear more than one branch Streptomyces coelicolor
metabolism the following assembly mechanism is proposed. Polymer synthesis starts with GlgE and its donor substrate, alpha-maltose 1-phosphate, yielding a linear oligomer with a degree of polymerization (of about 16) sufficient for GlgB to introduce a branch. Branching involves strictly intrachain transfer to generate a C chain (the only constituent chain to retain its reducing end), which now bears an A chain (a nonreducing end terminal branch that does not itself bear a branch). GlgE preferentially extends A chains allowing GlgB to act iteratively to generate new A chains emanating from B chains (nonterminal branches that themselves bear a branch). Although extension and branching occur primarily with A chains, the other chain types are sometimes extended and branched such that some B chains (and possibly C chains) bear more than one branch Mycobacterium tuberculosis