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Literature summary for 2.4.1.18 extracted from
- Glycogen branching enzyme controls cellular iron homeostasis via iron regulatory protein 1 and mitoNEET (2019), Nat. Commun., 10, 5463 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AGBE | - |
Drosophila melanogaster |
| glycogen branching enzyme | - |
Drosophila melanogaster |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme mutations cause porphyria | Drosophila melanogaster |
| physiological function | the enzyme is a regulator of iron homeostasis. The enzyme interacts physically with the holoform of iron regulatory protein 1A (IRP1A) and Cisd2, an ortholog of vertebrate mitoNEET. This synergistic interaction ensures that holo-IRP1A remains functional | Drosophila melanogaster |
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