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Literature summary for 2.4.1.174 extracted from

  • Sakai, D.; Nakai, T.; Hiraishi, S.; Nakamura, Y.; Ando, K.; Naiki, M.; Watanabe, M.
    Upregulation of glycosaminoglycan synthesis by neurotropin in nucleus pulposus cells via stimulation of chondroitin sulfate N-acetylgalactosaminyltransferase 1 a new approach to attenuation of intervertebral disc degeneration (2018), PLoS ONE, 13, e0202640 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.174

Cloned(Commentary)

Cloned (Comment) Organism
gene CSGALNACT1, quantitative real-time PCR enzyme expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan Homo sapiens
-
 UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosyl-proteoglycan
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TDX6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
nucleus pulposus
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan
-
 Homo sapiens UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosyl-proteoglycan
-
 ?

Synonyms

Synonyms Comment Organism
chondroitin sulfate N-acetylgalactosaminyltransferase 1
-
 Homo sapiens
CSGalNAcT-1
-
 Homo sapiens
CSGalNAcT1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens induction of gene CSGalNAcT-2 by NTP is much lower compared to CSGalNAcT-1 additional information
Homo sapiens enzyme expression is induced by Neutropin (NTP). Neurotropin activates the phosphatidylinositol 3-kinase-AKT pathway and AKT stimulation, it stimulate glycosaminoglycan synthesis through upregulation of expression of mRNA for chondroitin sulfate N-acetylgalactosaminyltransferase 1. Gene expression profiling shows over 2fold upregulation of 697 genes in response to Neurotropin treatment. Upregulation of IGF1, ANG1, and CSGALNACT1 expression by NTP. Neurotropin (NTP) is a nonprotein extract from inflamed rabbit skin inoculated with vaccinia virus, it has been widely used in Japan and China as an analgesic drug for treatment of chronic pain, such as LBP, postherpetic neuralgia, neck-shoulder-arm syndrome, hyperesthesia of subacute myelo-optic neuropathy, and fibromyalgia. Addition of NTP to the culture medium of nucleus pulposus cells enhances proteoglycan synthesis to halt progressive intervertebral disc (IVD) degeneration up

General Information

General Information Comment Organism
physiological function chondroitin sulfate N-acetylgalactosaminyltransferase 1 initiates synthesis of chondroitin sulfate side chains attached to a core protein of aggrecan, which is a predominant disc matrix component Homo sapiens