Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.174 extracted from

  • Yoshioka, N.; Miyata, S.; Tamada, A.; Watanabe, Y.; Kawasaki, A.; Kitagawa, H.; Takao, K.; Miyakawa, T.; Takeuchi, K.; Igarashi, M.
    Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis (2017), Mol. Brain, 10, 47 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.174

Protein Variants

Protein Variants Comment Organism
additional information generation of mice that are deficient in the CS synthesizing enzyme, CSGalNAcT1 (T1KO) Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular extracellular matrix Mus musculus
-
-
plasma membrane
-
 Mus musculus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan Mus musculus
-
 UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosyl-proteoglycan
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BJQ9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan
-
 Mus musculus UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosyl-proteoglycan
-
 ?

Synonyms

Synonyms Comment Organism
CSGalNAcT1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction abnormalities in perineuronal nets and behavior are observed in mice lacking CSGalNAcT1. Loss of this enzyme reduces the amount of chondroitin sulfate (CS) by approximately 50% in various brain regions. The amount of CS in perineuronal nets (PNNs) is also diminished in T1KO compared to wild-type mice, although the amount of a major CS proteoglycan core protein, aggrecan, is not changed. In T1KO, abnormalities in several behavioral tests, including the open-field test, acoustic startle response, and social preference are observed. Phenotype, overview Mus musculus
metabolism CSGalNAcT1 is a key enzyme in chondroitin sulfate synthesis. Chondroitin sulfate (CS) is an important glycosaminoglycan and is mainly found in the extracellular matrix as CS proteoglycans. In the brain, CS proteoglycans are highly concentrated in perineuronal nets (PNNs), which surround synapses and modulate their functions Mus musculus
physiological function enzyme CSGalNAcT1 is important for plasticity, probably due to regulation of CS-dependent perineuronal nets (PNNs). It plays an important role in supplying CS for PNN development and brain functions related to several characteristic behaviors Mus musculus