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Literature summary for 2.4.1.174 extracted from

  • Zhang, L.; Ren, X.; Chen, Y.; Gao, Y.; Wang, N.; Lu, Z.; Gao, L.; Qin, L.; Wang, Y.; Gao, H.; Li, K.; Jiang, L.; Cui, H.; Liu, C.; Zhang, Y.; Qi, X.; Wang, X.
    Chondroitin sulfate N-acetylgalactosaminyltransferase-2 contributes to the replication of infectious bursal disease virus via interaction with the capsid protein VP2 (2015), Viruses, 7, 1474-1491.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.174

Cloned(Commentary)

Cloned (Comment) Organism
gene CSGalNAcT2, cloning from DF-1 cells, overexpression in DF1 cells, semiquantitative real-time RT-PCR enzyme expression analysis, interaction analysis of enzyme CSGalNAcT2 with IBDV viral capsid protein VP2using the yeast two-hybridization assay Gallus gallus

Protein Variants

Protein Variants Comment Organism
additional information overexpression and siRNA-mediated knockdown of gene CSGalNAcT2 in DF1 cells Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
brefeldin A
-
 Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus confocal microscopy analysis of isozyme localization Gallus gallus 5794
-

Organism

Organism UniProt Comment Textmining
Gallus gallus E1C2T4 gene csgalnact2
-

Source Tissue

Source Tissue Comment Organism Textmining
DF-1 cell
-
 Gallus gallus
-
fibroblast
-
 Gallus gallus
-

Synonyms

Synonyms Comment Organism
chondroitin sulfate N-acetylgalactosaminyltransferase-2
-
 Gallus gallus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Gallus gallus

Expression

Organism Comment Expression
Gallus gallus CSGalNAcT2 gene expression is upregulated during infectious bursal disease virus, IBDV, infection up

General Information

General Information Comment Organism
malfunction knockdown of CSGalNAcT2 inhibits infectious bursal disease virus replication involving the integrity of the Golgi apparatus Gallus gallus
physiological function chondroitin sulfate N-acetylgalactosaminyltransferase-2 contributes to the replication of infectious bursal disease virus, IBDV, via interaction with capsid protein VP2. Overexpression of CSGalNAcT2 promotes IBDV replication in DF1 cells involving the integrity of the Golgi apparatus Gallus gallus