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Literature summary for 2.4.1.174 extracted from

  • Takeuchi, K.; Yoshioka, N.; Higa Onaga, S.; Watanabe, Y.; Miyata, S.; Wada, Y.; Kudo, C.; Okada, M.; Ohko, K.; Oda, K.; Sato, T.; Yokoyama, M.; Matsushita, N.; Nakamura, M.; Okano, H.; Sakimura, K.; Kawano, H.; Kitagawa, H.; Igarashi, M.
    Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury (2013), Nat. Commun., 4, 2740.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.174

Cloned(Commentary)

Cloned (Comment) Organism
gene Csgalnact1 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of RNAi-mediated gene Csgalnact1 knockout mice, mutant T1KO. T1KO mice are viable, but they have abnormal bone development and 10% shorter bodies compared to wild-type mice. Heparan sulfate synthesis increases in injured spinal cords of T1KO mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information heparan sulfate-synthesis enzymes inhibits chondroitin sulfate as extracellular inhibitor of axon growth Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan Mus musculus
-
 UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BJQ9 gene csgalnact1
-

Source Tissue

Source Tissue Comment Organism Textmining
cartilage
-
 Mus musculus
-
spinal cord
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl-(1->3)-D-galactosyl-proteoglycan
-
 Mus musculus UDP + N-acetyl-D-galactosaminyl-(1->4)-beta-D-glucuronyl-(1->3)-beta-D-galactosylproteoglycan
-
 ?

Synonyms

Synonyms Comment Organism
chondroitin sulphate N-acetylgalactosaminyl-transferase-1
-
 Mus musculus
CS N-acetylgalactosaminyltransferase-1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction mice carrying a gene knockout for chondroitin sufate N-acetylgalactosaminyltransferase-1, mutant T1KO, recover more completely from spinal cord injury than wild-type mice and even chondroitinase ABC-treated mice. Synthesis of heparan sulfate, a glycosaminoglycan promoting axonal growth, is also upregulated in TI knockout mice because heparan sulfate-synthesis enzymes are induced in the mutant neurons. Chondroitinase ABC treatment never induces heparan sulfate upregulation. T1KO mice are viable, but they have abnormal bone development and 10% shorter bodies compared to wild-type mice. Reduced chondroitin sulfate levels are associated with reduced scar formation in T1KO mice. Phenotype of enzyme knockout mutant mice, overview Mus musculus
metabolism chondroitin sulfate N-acetylgalactosaminyl-transferase-1 is a key enzyme in chondroitin sulfate biosynthesis Mus musculus