Literature summary for 2.4.1.150 extracted from

Peng, F.; He, Q.; Cheng, C.; Pan, J.
GCNT2 induces epithelial-mesenchymal transition and promotes migration and invasion in esophageal squamous cell carcinoma cells (2019), Cell Biochem. Funct., 37, 42-51 .

Search for more literature for 2.4.1.150

Application

Application	Comment	Organism
diagnostics	GCNT2 is a regulator of epithelial-mesenchymal transition (EMT) and a candidate prognostic indicator of outcome in esophageal squamous cell carcinoma (ESCC) patients	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N0V5	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
esophageal squamous cell carcinoma cell	expression of GCNT2 is significantly higher in tumour tissues than in paratumour tissues, tissue microarray analysis	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
GCNT2	-	Homo sapiens
I-branching N-acetylglucosaminyltransferase	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	manipulation of I-branching N-acetylglucosaminyltransferase (GCNT2) expression in esophageal squamous cell carcinoma cells has no effect on cell proliferation. Overexpression of GCNT2 promotes the migration and invasion, and this effect is associated with increased expression of N-cadherin and vimentin and decreased expression of E-cadherin in KYSE30 and EC9706 cells. Knockdown of GCNT2 decreased the expression of N-cadherin and vimentin, increases the expression of E-cadherin, and inhibits the migration and invasion in KYSE150 and EC109 cells	Homo sapiens
physiological function	overall survival is significantly lower in esophageal squamous cell carcinoma patients with high GCNT2 expression than those with low GCNT2 expression	Homo sapiens

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Release 2023.1 (January 2023)