BRENDA - Enzyme Database
show all sequences of 2.4.1.15

Trehalose 6-phosphate synthase from Selaginella lepidophylla: purification and properties

Valenzuela-Soto, E.M.; Marquez-Escalante, J.A.; Iturriaga, G.; Figueroa-Soto, C.G.; Biochem. Biophys. Res. Commun. 313, 314-319 (2004)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
D-fructose
-
Selaginella lepidophylla
D-fructose 6-phosphate
-
Selaginella lepidophylla
D-glucose
-
Selaginella lepidophylla
additional information
no effect by sucrose and trehalose up tp 0.4 M
Selaginella lepidophylla
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
no effect by sucrose and trehalose up to 0.4 M, no substrate and product inhibition
Selaginella lepidophylla
proline
-
Selaginella lepidophylla
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
activates at physiological concentrations
Selaginella lepidophylla
K+
activates maximal at 50 mM by 176%, 160% at 400 mM
Selaginella lepidophylla
Mg2+
activates at low concentration up to 5 mM
Selaginella lepidophylla
additional information
no effect by Na+
Selaginella lepidophylla
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
additional information
-
3 aggregation forms of 230, 440, and 660 kDa contain polypeptides of 50, 67, and 115 kDa polypeptides, only the 440 kDa form is catalytically active, native PAGE
Selaginella lepidophylla
115000
-
4 * 115000, SDS-PAGE
Selaginella lepidophylla
440000
-
native PAGE
Selaginella lepidophylla
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
UDP-alpha-D-glucose + D-glucose 6-phosphate
Selaginella lepidophylla
step in trehalose biosynthesis
UDP + alpha,alpha-trehalose 6-phosphate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Selaginella lepidophylla
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
no glycoprotein
-
Selaginella lepidophylla
Purification (Commentary)
Commentary
Organism
native enzyme 50fold by ammonium sulfate fractionation, gel filtration, and nickel-resin affinity chromatography
Selaginella lepidophylla
Source Tissue
Source Tissue
Commentary
Organism
Textmining
plant
-
Selaginella lepidophylla
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
7.05
-
purified enzyme
Selaginella lepidophylla
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
substrate specificity, no activity with trehalose, maltose, or fructose as acceptor substrates
657760
Selaginella lepidophylla
?
-
-
-
-
UDP-alpha-D-glucose + D-glucose 6-phosphate
step in trehalose biosynthesis
657760
Selaginella lepidophylla
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
UDP-alpha-D-glucose + D-glucose 6-phosphate
the enzyme is highly specific for UDP-glucose and D-glucose 6-phosphate
657760
Selaginella lepidophylla
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
UDP-glucose + D-fructose 6-phosphate
16% of the activity with D-glucose 6-phosphate
657760
Selaginella lepidophylla
UDP + ?
-
-
-
?
UDP-glucose + D-galactose
17% of the activity with D-glucose 6-phosphate
657760
Selaginella lepidophylla
UDP + ?
-
-
-
?
UDP-glucose + D-glucose
28% of the activity with D-glucose 6-phosphate
657760
Selaginella lepidophylla
UDP + ?
-
-
-
?
UDP-glucose + lactose
10% of the activity with D-glucose 6-phosphate
657760
Selaginella lepidophylla
UDP + ?
-
-
-
?
UDP-glucose + sucrose
19% of the activity with D-glucose 6-phosphate
657760
Selaginella lepidophylla
UDP + ?
-
-
-
?
Subunits
Subunits
Commentary
Organism
tetramer
4 * 115000, SDS-PAGE
Selaginella lepidophylla
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
35
-
assay at
Selaginella lepidophylla
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
-
Selaginella lepidophylla
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
5
10
stable
Selaginella lepidophylla
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Selaginella lepidophylla
115 kDa enzyme polypeptide, isoelectric focusing
-
4.55
Selaginella lepidophylla
67 kDa enzyme polypeptide, isoelectric focusing
-
4.69
Selaginella lepidophylla
50 kDa enzyme polypeptide, isoelectric focusing
-
4.83
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
D-fructose
-
Selaginella lepidophylla
D-fructose 6-phosphate
-
Selaginella lepidophylla
D-glucose
-
Selaginella lepidophylla
additional information
no effect by sucrose and trehalose up tp 0.4 M
Selaginella lepidophylla
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
no effect by sucrose and trehalose up to 0.4 M, no substrate and product inhibition
Selaginella lepidophylla
proline
-
Selaginella lepidophylla
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
activates at physiological concentrations
Selaginella lepidophylla
K+
activates maximal at 50 mM by 176%, 160% at 400 mM
Selaginella lepidophylla
Mg2+
activates at low concentration up to 5 mM
Selaginella lepidophylla
additional information
no effect by Na+
Selaginella lepidophylla
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
additional information
-
3 aggregation forms of 230, 440, and 660 kDa contain polypeptides of 50, 67, and 115 kDa polypeptides, only the 440 kDa form is catalytically active, native PAGE
Selaginella lepidophylla
115000
-
4 * 115000, SDS-PAGE
Selaginella lepidophylla
440000
-
native PAGE
Selaginella lepidophylla
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
UDP-alpha-D-glucose + D-glucose 6-phosphate
Selaginella lepidophylla
step in trehalose biosynthesis
UDP + alpha,alpha-trehalose 6-phosphate
-
-
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
no glycoprotein
-
Selaginella lepidophylla
Purification (Commentary) (protein specific)
Commentary
Organism
native enzyme 50fold by ammonium sulfate fractionation, gel filtration, and nickel-resin affinity chromatography
Selaginella lepidophylla
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
plant
-
Selaginella lepidophylla
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
7.05
-
purified enzyme
Selaginella lepidophylla
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
substrate specificity, no activity with trehalose, maltose, or fructose as acceptor substrates
657760
Selaginella lepidophylla
?
-
-
-
-
UDP-alpha-D-glucose + D-glucose 6-phosphate
step in trehalose biosynthesis
657760
Selaginella lepidophylla
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
UDP-alpha-D-glucose + D-glucose 6-phosphate
the enzyme is highly specific for UDP-glucose and D-glucose 6-phosphate
657760
Selaginella lepidophylla
UDP + alpha,alpha-trehalose 6-phosphate
-
-
-
?
UDP-glucose + D-fructose 6-phosphate
16% of the activity with D-glucose 6-phosphate
657760
Selaginella lepidophylla
UDP + ?
-
-
-
?
UDP-glucose + D-galactose
17% of the activity with D-glucose 6-phosphate
657760
Selaginella lepidophylla
UDP + ?
-
-
-
?
UDP-glucose + D-glucose
28% of the activity with D-glucose 6-phosphate
657760
Selaginella lepidophylla
UDP + ?
-
-
-
?
UDP-glucose + lactose
10% of the activity with D-glucose 6-phosphate
657760
Selaginella lepidophylla
UDP + ?
-
-
-
?
UDP-glucose + sucrose
19% of the activity with D-glucose 6-phosphate
657760
Selaginella lepidophylla
UDP + ?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
tetramer
4 * 115000, SDS-PAGE
Selaginella lepidophylla
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
35
-
assay at
Selaginella lepidophylla
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
-
Selaginella lepidophylla
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
5
10
stable
Selaginella lepidophylla
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Selaginella lepidophylla
115 kDa enzyme polypeptide, isoelectric focusing
-
4.55
Selaginella lepidophylla
67 kDa enzyme polypeptide, isoelectric focusing
-
4.69
Selaginella lepidophylla
50 kDa enzyme polypeptide, isoelectric focusing
-
4.83
Other publictions for EC 2.4.1.15
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743566
Chen
A trehalose biosynthetic enzy ...
Arthrobacter alpinus
PLoS Genet.
13
e1007062
2017
-
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1
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1
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-
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2
2
-
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-
736372
Ozer Uyar
Cloning and expression of treh ...
Rhizopus oryzae
J. Basic Microbiol.
56
459-468
2016
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1
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1
1
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4
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1
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1
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1
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1
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1
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1
1
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1
1
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735637
Delorge
Trehalose-6-phosphate synthase ...
Arabidopsis thaliana
Biochem. J.
466
283-290
2015
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-
1
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4
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3
3
-
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736474
Petitjean
Yeast tolerance to various str ...
Saccharomyces cerevisiae
J. Biol. Chem.
290
16177-16190
2015
-
-
-
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4
-
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1
-
4
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1
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4
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1
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1
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3
3
-
-
-
737083
Hespeels
Against all odds: trehalose-6- ...
Adineta vaga
PLoS ONE
10
e0131313
2015
-
-
1
-
-
-
-
-
-
-
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-
6
-
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1
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1
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1
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-
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-
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-
2
2
-
-
-
727099
Gao
Enzymatic and regulatory prope ...
Thermoplasma acidophilum
Biochimie
101
215-220
2014
3
-
1
-
-
-
15
4
-
5
1
1
4
3
-
-
1
-
-
-
1
-
9
1
1
1
2
-
1
2
2
-
-
-
-
3
-
1
-
-
-
-
-
15
-
4
-
5
1
1
4
-
-
1
-
-
1
-
9
1
1
1
2
-
1
2
2
-
-
1
1
-
-
-
729302
Sengupta
Purification, characterization ...
Saccharomyces cerevisiae
Biochim. Biophys. Acta
1840
1861-1871
2014
1
-
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2
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1
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1
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736176
Shi
Trehalose metabolism in the bl ...
Callinectes sapidus
Gene
536
105-113
2014
-
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1
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4
-
8
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4
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4
1
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4
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4
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13
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4
4
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1
4
-
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-
736565
Yadav
The sucrose-trehalose 6-phosph ...
Arabidopsis thaliana, Arabidopsis thaliana Col-0
J. Exp. Bot.
65
1051-1068
2014
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737237
Lopienska-Biernat
-
Properties of trehalose-6-phos ...
Anisakis simplex
Russ. J. Nematol.
22
131-140
2014
1
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-
6
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3
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1
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1
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1
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6
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3
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1
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1
1
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1
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728601
Zaparty
The first prokaryotic trehalos ...
Thermoproteus tenax, Thermoproteus tenax ATCC 35583, Thermoproteus tenax DSM 2078
PLoS One
8
e61354
2013
1
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1
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3
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9
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1
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6
1
1
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1
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1
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3
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1
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6
1
1
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1
1
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736120
Tischler
Trehalose phosphate synthases ...
Rhodococcus opacus 1CP, Rhodococcus opacus
FEMS Microbiol. Lett.
342
113-122
2013
1
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1
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-
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1
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4
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6
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1
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4
10
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2
1
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2
1
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1
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2
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1
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4
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2
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4
10
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2
1
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2
1
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2
4
-
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-
736579
Dmitryjuk
Purification and partial bioch ...
Ascaris suum
J. Helminthol.
87
212-221
2013
-
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1
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4
-
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3
1
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3
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1
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2
1
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4
1
1
1
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1
1
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1
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2
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-
8
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-
6
2
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2
-
3
2
-
4
2
2
2
-
-
2
2
-
2
-
1
2
-
-
-
719186
Kondrak
Effects of yeast trehalose-6-p ...
Saccharomyces cerevisiae
BMC Plant Biol.
12
74
2012
-
-
1
-
1
-
-
-
-
-
-
2
-
4
-
-
-
-
-
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2
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2
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2
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2
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2
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719600
Kern
Trehalose-6-phosphate synthase ...
Ctenocephalides felis, Drosophila melanogaster
Insect Mol. Biol.
21
456-471
2012
-
2
2
-
-
-
64
-
-
-
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2
-
6
-
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2
-
-
-
-
-
4
-
2
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-
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2
-
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62
-
2
2
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-
-
62
64
-
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2
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2
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4
-
2
-
-
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2
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2
2
-
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-
720422
Zhang
A trehalose-6-phosphate syntha ...
Penaeus chinensis
Mol. Biol. Rep.
39
10219-10225
2012
-
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Arginine mediated purification ...
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Enhanced thermotolerance for e ...
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Regulation of expression of tr ...
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Extremophiles
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The sugar sensor, trehalose-6- ...
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2011
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Avonce
The Cytophaga hutchinsonii ChT ...
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Mol. Biol. Evol.
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The catalytic efficiency of tr ...
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Gomez
AtTPS1-mediated trehalose 6-ph ...
Arabidopsis thaliana
Plant J.
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2010
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Martinez-Esparza
Role of trehalose-6P phosphata ...
Candida albicans
Int. J. Med. Microbiol.
299
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2009
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702423
Chaudhuri
Studies on substrate specifici ...
Saccharomyces cerevisiae
Biochim. Biophys. Acta
1790
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2009
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Xu
Identification of a novel gene ...
Helicoverpa armigera
Glycobiology
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2009
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704031
Cui
-
Isolation and characterization ...
Locusta migratoria manilensis
Insect Sci.
16
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Cai
Trehalose-6-phosphate synthase ...
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J. Biosci. Bioeng.
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2009
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682433
Chary
Trehalose-6-phosphate synthase ...
Arabidopsis thaliana
Plant Physiol.
146
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2008
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Lee
Three trehalose synthetic path ...
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Appl. Microbiol. Biotechnol.
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2008
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Chaudhuri
Aggregation dependent enhancem ...
Saccharomyces cerevisiae
Biochim. Biophys. Acta
1780
289-297
2008
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Suarez
Improvement of drought toleran ...
Rhizobium etli
Mol. Plant Microbe Interact.
21
958-966
2008
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694773
Stiller
Effects of drought on water co ...
Saccharomyces cerevisiae
Planta
227
299-308
2008
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695123
Chung
A trehalose 6-phosphate syntha ...
Callinectes sapidus
Saline Syst.
4
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2008
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702847
Tao
-
Transformation of maize with t ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae AS.1416
Biotechnology
7
258-265
2008
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Cardoso
Biochemical and genetic charac ...
Propionibacterium freudenreichii
Microbiology
153
270-280
2007
1
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1
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3
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1
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675977
Conlin
The natural osmolyte trehalose ...
Selaginella lepidophylla
Mol. Cell. Biol.
27
1505-1515
2007
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Almeida
Immunogold localization of tre ...
Arabidopsis thaliana
Protoplasma
230
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2007
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682472
Miranda
A bifunctional TPS-TPP enzyme ...
Saccharomyces cerevisiae
Planta
226
1411-1421
2007
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694755
Geelen
-
Trehalose-6-P synthase AtTPS1 ...
Arabidopsis thaliana
Plant Sci.
173
426-437
2007
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673990
Petzold
Characterization and regulatio ...
Cryptococcus neoformans var. grubii
Infect. Immun.
74
5877-5887
2006
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674381
Wu
Molecular cloning, characteriz ...
Ginkgo biloba
J. Biochem. Mol. Biol.
39
158-166
2006
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674967
Leyman
Trehalose-6-phosphate synthase ...
Arabidopsis thaliana
J. Biotechnol.
121
309-317
2006
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676512
Gomez
Delayed embryo development in ...
Arabidopsis thaliana
Plant J.
46
69-84
2006
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657904
Gomez
The role of trehalose-6-phosph ...
Arabidopsis thaliana
Biochem. Soc. Trans.
33
280-282
2005
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658670
Silva
Trehalose biosynthesis in Ther ...
Thermus thermophilus, Thermus thermophilus RQ-1
Extremophiles
9
29-36
2005
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4
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1
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Trehalose-6-phosphate synthase ...
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488618
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Trehalose-phosphate synthase o ...
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488619
Gibson
Characterization of Escherichi ...
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Roles of trehalose phosphate s ...
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2001
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Reconstitution of ethanolic fe ...
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488614
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Characterization of a bifuncti ...
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1
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Three pathways for trehalose b ...
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2000
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3
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Isolation and molecular charac ...
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488608
Arisan-Atac
Trehalose-6-phosphate synthase ...
Aspergillus niger
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1996
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1
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Inhibition of the trehalose-P ...
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Noventa-Jordao
Effects of temperature shifts ...
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378
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Trehalose-6-P synthase is disp ...
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742610
Kaasen
Analysis of the otsBA operon ...
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1
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488594
Lippert
Biosynthesis and function of t ...
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63
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1993
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Characterization of the 56-kDa ...
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Vandercammen
Characterization of trehalose- ...
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Killick
Trehalose 6-phosphate synthase ...
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196
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4
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Pan
Studies on the trehalose-phosp ...
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Elbein
Effects of polyanions and poly ...
Mycolicibacterium smegmatis
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6
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3
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3
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7
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1
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3
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5
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1
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The enzymes of glycogen and tr ...
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2
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4
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1
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3
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1
1
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1
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1
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4
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2
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4
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3
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1
1
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1
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488600
Lornitzo
Purification and properties of ...
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2
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1
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2
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1
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Candy
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1
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1
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1
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1
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1
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488602
Cabib
The biosynthesis of trehalose ...
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2
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1
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1
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1
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1
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1
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1
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2
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1
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1
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1
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1
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1
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