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Literature summary for 2.4.1.144 extracted from

  • Deng, Q.; Yin, N.; Chen, Y.; Shan, N.; Liu, X.; Qi, H.
    Downregulated N-acetylglucosaminyltransferase III is involved in attenuating trophoblast migration and invasion under hypoxia-reoxygenation condition (2019), J. Matern. Fetal. Neonatal. Med., 32, 2369-2375 .
    View publication on PubMed
Search for more literature for 2.4.1.144

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] Homo sapiens
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 UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-GlcNAc-(1->4)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q09327
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Source Tissue

Source Tissue Comment Organism Textmining
chorionic villus
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 Homo sapiens
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cytotrophoblast
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 Homo sapiens
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decidua
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 Homo sapiens
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HTR-8/SVneo cell decreased expression of GnT-III in H/R-exposed HTR8/SVneo cells, and the invasive and migratory abilities of HTR8/SVneo cells were attenuated, too Homo sapiens
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additional information human first trimester villous tissues from normal pregnancies and third trimester placentas from pregnancies with or without preeclampsia (PE) are used for the detection of GnTIII expression Homo sapiens
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placenta enzyme GnT-III is strongly expressed in cytotrophoblast (CTBs), syncytiotrophoblast (STBs), and the trophoblast columns (TCs) of human placental villi, and decidual cells in maternal decidua. The expression of GnT-III is decreased in preeclampsia placentas compared with the normal control placentas Homo sapiens
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syncytiotrophoblast
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 Homo sapiens
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trophoblast
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
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 Homo sapiens UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-GlcNAc-(1->4)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
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Synonyms

Synonyms Comment Organism
GnT-III
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 Homo sapiens
N-acetylglucosaminyltransferase III
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 Homo sapiens

General Information

General Information Comment Organism
malfunction downregulated N-acetylglucosaminyltransferase III is involved in attenuating trophoblast migration and invasion under hypoxia-reoxygenation condition. Excessive oxidative stress can decrease GnT-III expression in trophoblast and the decreased expression of GnT-III may be involved in the development of preeclampsia. Clinical characteristics of preeclampsia group comparedwith normal pregnancy group, overview Homo sapiens
metabolism GnT-III is considered to be a key glycosyltransferase in the N-glycan biosynthetic pathway because the introduction of the bisecting GlcNAc residue suppresses further processing and elongation of the N-glycans catalyzed by GnT-V. So, in the tumor context, GnT-III and GnT-V have generally a dual role where GnT-III acts as metastases suppressors whereas GnT-V is associated with increased malignancy and metastasis Homo sapiens
physiological function N-acetylglucosaminyltransferases III (GnT-III) is one of the most important N-glycosyltransferases encoded by the MGAT3 gene. GnT-III catalyzes the addition of GlcNAc via b1-4 linkage to the b-mannose of the mannosyl core of N-glycans. N-acetylglucosaminyltransferase III (GnT-III) is correlated with tumor invasion and metastasis. GnT-III is an important regulator at the maternal-fetal interface during early pregnancy Homo sapiens