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Literature summary for 2.4.1.102 extracted from

  • Liu, J.; Jin, C.; Cherian, R.M.; Karlsson, N.G.; Holgersson, J.
    O-glycan repertoires on a mucin-type reporter protein expressed in CHO cell pools transiently transfected with O-glycan core enzyme cDNAs (2015), J. Biotechnol., 199, 77-89.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene GCNT1 , recombinant expression in CHO-K1 cells. Glycosylation-related genes in CHO-K1 cells are present, but strictly suppressed and regulated. CHO cells are transiently co-transfected with plasmids encoding extended C1 beta3GnT3, C2 beta6GnT1, or C3 beta3GnT6 with or without ST6Gal I or CHST4, respectively, and resulting O-glycan and core chain spectrum, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q02742 gene GCNT1
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Source Tissue

Source Tissue Comment Organism Textmining
colorectal adenocarcinoma cell
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 Homo sapiens
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HT-29 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
beta1,6-N-acetylglucosaminyltransferase
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 Homo sapiens
C2 beta6GnT1
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 Homo sapiens
core 2 beta1,6-N-acetylglucosaminyltransferase I
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 Homo sapiens

General Information

General Information Comment Organism
metabolism O-glycan biosynthesis pathways and proposed O-glycan structures of selected glycosyltransferases, overview. Core 1 dominates the O-glycan repertoire. Core 1 can be further elongated by extended C1 beta3GnT3 enzyme, EC 2.4.1.146, to form extended core 1 structure, or be modified by C2 beta6GnT1 enzyme to form core 2 O-glycans. Three core 2 enzymes, C2 beta6GnT1, 2, and 3, are responsible for biosynthesis of core 2 O-glycans. C2 beta6GnT1 and 3 are almost exclusively responsible for biosynthesis of the core 2 branch, while C2 beta6GnT2 shows a significant core 4 and I-branching activity. Regulation of O-glycan biosynthesis, overview Homo sapiens