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Literature summary for 2.3.3.4 extracted from
- Purification and properties of 2-decylhomocitrate synthase from Penicillium spiculisporum (1973), Eur. J. Biochem., 38, 32-39.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5,5'-dithiobis(2-nitrobenzoic acid) | enzyme inactivation, lauroyl-CoA or palmitoyl-CoA protects | Talaromyces trachyspermus |  |
| oxaloacetate | competitive to 2-oxoglutarate | Talaromyces trachyspermus | |
| palmitoyl-CoA | partially competitive with lauroyl-CoA | Talaromyces trachyspermus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
lauroyl-CoA | - |
Talaromyces trachyspermus | |
| 0.75 | - |
2-oxoglutarate | - |
Talaromyces trachyspermus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
? * 43000, SDS-PAGE | Talaromyces trachyspermus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dodecanoyl-CoA + H2O + 2-oxoglutarate | Talaromyces trachyspermus | - |
(3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Talaromyces trachyspermus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Talaromyces trachyspermus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.25 | - |
- |
Talaromyces trachyspermus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| decanoyl-CoA + H2O + 2-oxoglutarate | - |
Talaromyces trachyspermus | (3S,4S)-3-hydroxydodecane-1,3,4-tricarboxylate + CoA | - |
? | |
| dodecanoyl-CoA + H2O + 2-oxoglutarate | - |
Talaromyces trachyspermus | (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | ? * 43000, SDS-PAGE | Talaromyces trachyspermus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.3 | - |
- |
Talaromyces trachyspermus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | 9 | 75% of maximal activity at pH 7.5 and 9 | Talaromyces trachyspermus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.4 | 0.8 | oxaloacetate | competitive inhibitor | Talaromyces trachyspermus | |
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