Protein Variants | Comment | Organism |
---|---|---|
Q84A | the mutant exhibits kcat values similar to that of the L-leucine inhibited wild type enzyme | Mycobacterium tuberculosis |
Y410F | the mutant exhibits kcat values similar to that of the L-leucine inhibited wild type enzyme | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-leucine | the enzyme retains approximately 10% activity in the presence of saturating concentrations of L-leucine | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O | Mycobacterium tuberculosis | - |
(2S)-2-isopropylmalate + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O | - |
Mycobacterium tuberculosis | (2S)-2-isopropylmalate + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-IPMS | - |
Mycobacterium tuberculosis |
Alpha-isopropylmalate synthase | - |
Mycobacterium tuberculosis |