Application | Comment | Organism |
---|---|---|
medicine | alpha-isopropylmalate synthase is a target for the design of new antitubercular therapeutics | Mycobacterium tuberculosis |
Cloned (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Protein Variants | Comment | Organism |
---|---|---|
Y410F | mutant, insensitive to L-leucine inhibition | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-leucine | feedback inhibition | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O | Mycobacterium tuberculosis | - |
(2S)-2-isopropylmalate + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
on a nickel-NTA, a Mono-Q and a Phenyl Sepharose column | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O | - |
Mycobacterium tuberculosis | (2S)-2-isopropylmalate + CoA | - |
? | |
alpha-ketoisovaleric acid + H2O + acetyl-CoA | - |
Mycobacterium tuberculosis | ? + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Alpha-isopropylmalate synthase | - |
Mycobacterium tuberculosis |
MtIPMS | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Mycobacterium tuberculosis |