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Literature summary for 2.3.3.13 extracted from

  • Teng-Leary, E.; Kohlhaw, G.B.
    Mechanism of feedback inhibition by leucine. Binding of leucine to wild-type and feedback-resistant alpha-isopropylmalate synthases and its structural consequences (1973), Biochemistry, 12, 2980-2986.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
leucine mechanism of feedback inhibition by Leu, binding of Leu to wild-type and feedback-resistant enzyme and its structural consequences Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
strain CV-19, and mutant strain CV-241 with a feed-back insensitive enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.008
-
leucine pH 6.8, 0.4 mM acetyl-CoA, 0.1 mM 2-oxo-3-methylbutanoate, wild-type enzyme Salmonella enterica subsp. enterica serovar Typhimurium
0.022
-
leucine pH 6.8, 0.8 mM acetyl-CoA, 4 mM 2-oxo-3-methylbutanoate, wild-type enzyme Salmonella enterica subsp. enterica serovar Typhimurium
3
-
leucine pH 6.8, 0.4 mM acetyl-CoA, 0.1 mM 2-oxo-3-methylbutanoate, feedback-resistent enzyme Salmonella enterica subsp. enterica serovar Typhimurium
20
-
leucine pH 6.8, 0.8 mM acetyl-CoA, 4 mM 2-oxo-3-methylbutanoate, feedback-resistent enzyme Salmonella enterica subsp. enterica serovar Typhimurium