Activating Compound | Comment | Organism | Structure |
---|---|---|---|
MgCl2 | - |
Gallus gallus | |
MgCl2 | optimal activity in 2.0 mM | Enterococcus faecalis |
Application | Comment | Organism |
---|---|---|
medicine | - |
Homo sapiens |
medicine | potential of the mevalonate pathway enzymes of enterococci as targets for antibiotics | Enterococcus faecalis |
Cloned (Comment) | Organism |
---|---|
- |
Gallus gallus |
cloning of a gene cluster encoding enzymes responsible for the mevalonate pathway | Streptomyces sp. |
expression of recombinant wild-type cytoplasmic and Cys129 mutant enzymes | Homo sapiens |
mvaS gene isolated, expressed in Escherichia coli from a pET28 vector | Enterococcus faecalis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0012 | - |
acetoacetyl-CoA | - |
Gallus gallus | |
0.0015 | - |
acetyl-CoA | - |
Blattella germanica | |
0.01 | - |
acetoacetyl-CoA | - |
Enterococcus faecalis | |
0.27 | - |
acetyl-CoA | - |
Gallus gallus | |
0.35 | - |
acetyl-CoA | - |
Enterococcus faecalis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Gallus gallus | 5737 | - |
cytoplasm | - |
Homo sapiens | 5737 | - |
cytoplasm | - |
Rattus norvegicus | 5737 | - |
cytoplasm | - |
Bos taurus | 5737 | - |
cytosol | - |
Gallus gallus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
cytosol | - |
Mesocricetus auratus | 5829 | - |
cytosol | - |
Blattella germanica | 5829 | - |
mitochondrion | - |
Gallus gallus | 5739 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
mitochondrion | - |
Sus scrofa | 5739 | - |
mitochondrion | - |
Bos taurus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
2 * 42000, calculated from amino acid sequence | Enterococcus faecalis |
45000 | - |
2 * 45000, SDS-PAGE | Enterococcus faecalis |
83900 | - |
analytical ultracentrifugation | Enterococcus faecalis |
84300 | - |
calculated from amino acid sequence | Enterococcus faecalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + acetoacetyl-CoA + H2O | Gallus gallus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir | |
acetyl-CoA + acetoacetyl-CoA + H2O | Staphylococcus aureus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Mus musculus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Homo sapiens | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir | |
acetyl-CoA + acetoacetyl-CoA + H2O | Rattus norvegicus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Sus scrofa | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir | |
acetyl-CoA + acetoacetyl-CoA + H2O | Bos taurus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Streptococcus pneumoniae | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Streptococcus pyogenes | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Mesocricetus auratus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Staphylococcus epidermidis | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Staphylococcus haemolyticus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Streptomyces sp. | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Borreliella burgdorferi | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Blattella germanica | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Enterococcus faecalis | isopentenyl diphosphate biosynthesis | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Blattella germanica | - |
cockroach | - |
Borreliella burgdorferi | - |
- |
- |
Bos taurus | - |
ox | - |
Enterococcus faecalis | - |
- |
- |
Gallus gallus | - |
avian | - |
Homo sapiens | - |
human | - |
Mesocricetus auratus | - |
syrian hamster, golden hamster | - |
Mus musculus | - |
mouse | - |
Rattus norvegicus | - |
rat | - |
Staphylococcus aureus | - |
- |
- |
Staphylococcus epidermidis | - |
- |
- |
Staphylococcus haemolyticus | - |
- |
- |
Streptococcus pneumoniae | - |
- |
- |
Streptococcus pyogenes | - |
- |
- |
Streptomyces sp. | - |
- |
- |
Sus scrofa | - |
pig | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
recombinant enzyme | Enterococcus faecalis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Gallus gallus | - |
liver | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Sus scrofa | - |
liver | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
10 | - |
- |
Enterococcus faecalis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Gallus gallus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Staphylococcus aureus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Mus musculus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Homo sapiens | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Rattus norvegicus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Sus scrofa | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Sus scrofa | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Bos taurus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Enterococcus faecalis | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Streptococcus pneumoniae | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Streptococcus pyogenes | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Mesocricetus auratus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Staphylococcus epidermidis | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Staphylococcus haemolyticus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Streptomyces sp. | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Borreliella burgdorferi | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Blattella germanica | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | isopentenyl diphosphate biosynthesis | Enterococcus faecalis | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Gallus gallus |
dimer | - |
Homo sapiens |
dimer | - |
Bos taurus |
dimer | 2 * 45000, SDS-PAGE | Enterococcus faecalis |
dimer | 2 * 42000, calculated from amino acid sequence | Enterococcus faecalis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Enterococcus faecalis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.8 | - |
- |
Enterococcus faecalis |