BRENDA - Enzyme Database show
show all sequences of 2.3.3.10

3-Hydroxy-3-methylglutaryl-CoA synthase: Participation of invariant acidic residues in formation of the acetyl-S-enzyme reaction intermediate

Chun, K.Y.; Vinarov, D.A.; Miziorko, H.M.; Biochemistry 39, 14670-14681 (2000)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
deficiency of the mitochondrial isoform correlates with human metabolic disease, cytosolic isoform is potentially useful target for drugs aimed at lowering cholesterol levels
Homo sapiens
Cloned(Commentary)
Commentary
Organism
expression vector pET-3d, cloned and expressed in Escherichia coli BL21 (DE3)
Gallus gallus
Inhibitors
Inhibitors
Commentary
Organism
Structure
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
-
Gallus gallus
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
-
Homo sapiens
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
-
Saccharomyces cerevisiae
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00119
-
acetoacetyl-CoA
-
Gallus gallus
0.0078
-
acetyl-CoA
mutant D159A
Gallus gallus
0.0081
-
acetyl-CoA
mutant D159A, acetyl-S-enzyme formation
Gallus gallus
0.014
-
acetyl-CoA
wild-type, acetyl-CoA hydrolysis
Gallus gallus
0.0227
-
acetyl-CoA
wild-type, acetyl-S-enzyme formation
Gallus gallus
0.033
-
acetyl-CoA
mutant D159A, acetyl-CoA hydrolysis
Gallus gallus
0.037
-
acetyl-CoA
mutant D203A
Gallus gallus
0.049
-
acetoacetyl-CoA
mutant D159A
Gallus gallus
0.066
-
acetoacetyl-CoA
mutant D99A
Gallus gallus
0.118
-
acetyl-CoA
mutant D64N
Gallus gallus
0.189
-
acetyl-CoA
mutant E63Q
Gallus gallus
0.207
-
acetyl-CoA
mutant D99A
Gallus gallus
0.29
-
acetyl-CoA
wild-type enzyme
Gallus gallus
0.319
-
acetyl-CoA
mutant D217A
Gallus gallus
0.354
-
acetyl-CoA
mutant E37Q
Gallus gallus
0.358
-
acetyl-CoA
mutant D282A
Gallus gallus
0.372
-
acetyl-CoA
mutant E121A
Gallus gallus
0.448
-
acetyl-CoA
mutant D203A, acetyl-S-enzyme formation
Gallus gallus
0.623
-
acetyl-CoA
mutant D99A, acetyl-S-enzyme formation
Gallus gallus
0.677
-
acetyl-CoA
mutant D124A
Gallus gallus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
cholesterogenic isoform
Arabidopsis thaliana
5737
-
cytoplasm
cholesterogenic isoform
Borreliella burgdorferi
5737
-
cytoplasm
cholesterogenic isoform
Caenorhabditis elegans
5737
-
cytoplasm
cholesterogenic isoform
Gallus gallus
5737
-
cytoplasm
cholesterogenic isoform
Homo sapiens
5737
-
cytoplasm
cholesterogenic isoform
Methanothermobacter thermautotrophicus
5737
-
cytoplasm
cholesterogenic isoform
Mus musculus
5737
-
cytoplasm
cholesterogenic isoform
Pinus sylvestris
5737
-
cytoplasm
cholesterogenic isoform
Rattus norvegicus
5737
-
cytoplasm
cholesterogenic isoform; cholesterogenic isoform
Saccharomyces cerevisiae
5737
-
cytoplasm
cholesterogenic isoform
Schizosaccharomyces pombe
5737
-
cytoplasm
cholesterogenic isoform
Sus scrofa
5737
-
cytosol
cholesterogenic isoform
Arabidopsis thaliana
5829
-
cytosol
;
Blattella germanica
5829
-
cytosol
cholesterogenic isoform
Borreliella burgdorferi
5829
-
cytosol
cholesterogenic isoform
Caenorhabditis elegans
5829
-
cytosol
-
Cricetulus griseus
5829
-
cytosol
cholesterogenic isoform
Gallus gallus
5829
-
cytosol
; cholesterogenic isoform
Homo sapiens
5829
-
cytosol
cholesterogenic isoform
Methanothermobacter thermautotrophicus
5829
-
cytosol
cholesterogenic isoform
Mus musculus
5829
-
cytosol
cholesterogenic isoform
Pinus sylvestris
5829
-
cytosol
cholesterogenic isoform
Rattus norvegicus
5829
-
cytosol
cholesterogenic isoform; cholesterogenic isoform
Saccharomyces cerevisiae
5829
-
cytosol
cholesterogenic isoform
Schizosaccharomyces pombe
5829
-
cytosol
cholesterogenic isoform
Sus scrofa
5829
-
cytosol
-
Mesocricetus auratus
5829
-
mitochondrion
ketogenic isoform
Arabidopsis thaliana
5739
-
mitochondrion
ketogenic isoform
Borreliella burgdorferi
5739
-
mitochondrion
ketogenic isoform
Caenorhabditis elegans
5739
-
mitochondrion
ketogenic isoform
Gallus gallus
5739
-
mitochondrion
ketogenic isoform
Homo sapiens
5739
-
mitochondrion
ketogenic isoform
Methanothermobacter thermautotrophicus
5739
-
mitochondrion
ketogenic isoform
Mus musculus
5739
-
mitochondrion
ketogenic isoform
Pinus sylvestris
5739
-
mitochondrion
ketogenic isoform
Rattus norvegicus
5739
-
mitochondrion
ketogenic isoform; ketogenic isoform
Saccharomyces cerevisiae
5739
-
mitochondrion
ketogenic isoform
Schizosaccharomyces pombe
5739
-
mitochondrion
ketogenic isoform
Sus scrofa
5739
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + acetoacetyl-CoA + H2O
Methanothermobacter thermautotrophicus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Mesocricetus auratus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Arabidopsis thaliana
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Blattella germanica
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Borreliella burgdorferi
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Caenorhabditis elegans
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Cricetulus griseus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Gallus gallus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Homo sapiens
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Mus musculus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Pinus sylvestris
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Rattus norvegicus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Saccharomyces cerevisiae
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Schizosaccharomyces pombe
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Sus scrofa
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Gallus gallus
key intermediate in cholesterogenic and ketogenic pathways, cholesterogenic isoform in cytosol, ketogenic isoform in mitochondria, committed step for both pathways
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
ir
acetyl-CoA + acetoacetyl-CoA + H2O
Homo sapiens
key intermediate in cholesterogenic and ketogenic pathways, cholesterogenic isoform in cytosol, ketogenic isoform in mitochondria, committed step for both pathways
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
ir
acetyl-CoA + acetoacetyl-CoA + H2O
Saccharomyces cerevisiae
key intermediate in cholesterogenic and ketogenic pathways, cholesterogenic isoform in cytosol, ketogenic isoform in mitochondria, committed step for both pathways
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
ir
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Arabidopsis thaliana
P54873
-
-
Blattella germanica
P54870
cockroach, cytosolic isoform 2
-
Blattella germanica
P54961
cockroach, cytosolic isoform 1
-
Borreliella burgdorferi
O51626
-
-
Caenorhabditis elegans
P54871
-
-
Cricetulus griseus
P13704
chinese hamster, cytosolic isoform
-
Gallus gallus
-
avian
-
Gallus gallus
P23228
chicken, cytosolic isoform
-
Homo sapiens
-
human
-
Homo sapiens
P54868
human, mitochondrial isoform
-
Homo sapiens
Q01581
human, cytosolic isoform
-
Mesocricetus auratus
-
syrian hamster, golden hamster
-
Methanothermobacter thermautotrophicus
-
-
-
Mus musculus
P54869
mouse, mitochondrial isoform
-
Pinus sylvestris
P93773
pine
-
Rattus norvegicus
P17425
rat, cytosolic isoform
-
Rattus norvegicus
P22791
rat, mitochondrial isoform
-
Saccharomyces cerevisiae
P54839
baker's yeast
-
Saccharomyces cerevisiae
-
-
-
Schizosaccharomyces pombe
P54874
-
-
Sus scrofa
O02734
pig, mitochondrial isoform
-
Purification (Commentary)
Commentary
Organism
several mutants partially purified
Gallus gallus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Gallus gallus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
ir
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Homo sapiens
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
ir
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Saccharomyces cerevisiae
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
ir
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Methanothermobacter thermautotrophicus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Mesocricetus auratus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Arabidopsis thaliana
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Blattella germanica
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Borreliella burgdorferi
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Caenorhabditis elegans
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Cricetulus griseus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Gallus gallus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Homo sapiens
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Mus musculus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Pinus sylvestris
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Rattus norvegicus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Saccharomyces cerevisiae
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Schizosaccharomyces pombe
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Sus scrofa
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
key intermediate in cholesterogenic and ketogenic pathways, cholesterogenic isoform in cytosol, ketogenic isoform in mitochondria, committed step for both pathways
488117
Gallus gallus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
ir
acetyl-CoA + acetoacetyl-CoA + H2O
key intermediate in cholesterogenic and ketogenic pathways, cholesterogenic isoform in cytosol, ketogenic isoform in mitochondria, committed step for both pathways
488117
Homo sapiens
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
ir
acetyl-CoA + acetoacetyl-CoA + H2O
key intermediate in cholesterogenic and ketogenic pathways, cholesterogenic isoform in cytosol, ketogenic isoform in mitochondria, committed step for both pathways
488117
Saccharomyces cerevisiae
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
ir
acetyl-CoA + H2O
-
488117
Gallus gallus
acetate + CoA
-
-
-
?
Application (protein specific)
Application
Commentary
Organism
medicine
deficiency of the mitochondrial isoform correlates with human metabolic disease, cytosolic isoform is potentially useful target for drugs aimed at lowering cholesterol levels
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expression vector pET-3d, cloned and expressed in Escherichia coli BL21 (DE3)
Gallus gallus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
-
Gallus gallus
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
-
Homo sapiens
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
-
Saccharomyces cerevisiae
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00119
-
acetoacetyl-CoA
-
Gallus gallus
0.0078
-
acetyl-CoA
mutant D159A
Gallus gallus
0.0081
-
acetyl-CoA
mutant D159A, acetyl-S-enzyme formation
Gallus gallus
0.014
-
acetyl-CoA
wild-type, acetyl-CoA hydrolysis
Gallus gallus
0.0227
-
acetyl-CoA
wild-type, acetyl-S-enzyme formation
Gallus gallus
0.033
-
acetyl-CoA
mutant D159A, acetyl-CoA hydrolysis
Gallus gallus
0.037
-
acetyl-CoA
mutant D203A
Gallus gallus
0.049
-
acetoacetyl-CoA
mutant D159A
Gallus gallus
0.066
-
acetoacetyl-CoA
mutant D99A
Gallus gallus
0.118
-
acetyl-CoA
mutant D64N
Gallus gallus
0.189
-
acetyl-CoA
mutant E63Q
Gallus gallus
0.207
-
acetyl-CoA
mutant D99A
Gallus gallus
0.29
-
acetyl-CoA
wild-type enzyme
Gallus gallus
0.319
-
acetyl-CoA
mutant D217A
Gallus gallus
0.354
-
acetyl-CoA
mutant E37Q
Gallus gallus
0.358
-
acetyl-CoA
mutant D282A
Gallus gallus
0.372
-
acetyl-CoA
mutant E121A
Gallus gallus
0.448
-
acetyl-CoA
mutant D203A, acetyl-S-enzyme formation
Gallus gallus
0.623
-
acetyl-CoA
mutant D99A, acetyl-S-enzyme formation
Gallus gallus
0.677
-
acetyl-CoA
mutant D124A
Gallus gallus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
cholesterogenic isoform
Arabidopsis thaliana
5737
-
cytoplasm
cholesterogenic isoform
Borreliella burgdorferi
5737
-
cytoplasm
cholesterogenic isoform
Caenorhabditis elegans
5737
-
cytoplasm
cholesterogenic isoform
Gallus gallus
5737
-
cytoplasm
cholesterogenic isoform
Homo sapiens
5737
-
cytoplasm
cholesterogenic isoform
Methanothermobacter thermautotrophicus
5737
-
cytoplasm
cholesterogenic isoform
Mus musculus
5737
-
cytoplasm
cholesterogenic isoform
Pinus sylvestris
5737
-
cytoplasm
cholesterogenic isoform
Rattus norvegicus
5737
-
cytoplasm
cholesterogenic isoform
Saccharomyces cerevisiae
5737
-
cytoplasm
cholesterogenic isoform
Schizosaccharomyces pombe
5737
-
cytoplasm
cholesterogenic isoform
Sus scrofa
5737
-
cytosol
cholesterogenic isoform
Arabidopsis thaliana
5829
-
cytosol
-
Blattella germanica
5829
-
cytosol
cholesterogenic isoform
Borreliella burgdorferi
5829
-
cytosol
cholesterogenic isoform
Caenorhabditis elegans
5829
-
cytosol
-
Cricetulus griseus
5829
-
cytosol
cholesterogenic isoform
Gallus gallus
5829
-
cytosol
cholesterogenic isoform
Homo sapiens
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
cholesterogenic isoform
Methanothermobacter thermautotrophicus
5829
-
cytosol
cholesterogenic isoform
Mus musculus
5829
-
cytosol
cholesterogenic isoform
Pinus sylvestris
5829
-
cytosol
cholesterogenic isoform
Rattus norvegicus
5829
-
cytosol
cholesterogenic isoform
Saccharomyces cerevisiae
5829
-
cytosol
cholesterogenic isoform
Schizosaccharomyces pombe
5829
-
cytosol
cholesterogenic isoform
Sus scrofa
5829
-
cytosol
-
Mesocricetus auratus
5829
-
mitochondrion
ketogenic isoform
Arabidopsis thaliana
5739
-
mitochondrion
ketogenic isoform
Borreliella burgdorferi
5739
-
mitochondrion
ketogenic isoform
Caenorhabditis elegans
5739
-
mitochondrion
ketogenic isoform
Gallus gallus
5739
-
mitochondrion
ketogenic isoform
Homo sapiens
5739
-
mitochondrion
ketogenic isoform
Methanothermobacter thermautotrophicus
5739
-
mitochondrion
ketogenic isoform
Mus musculus
5739
-
mitochondrion
ketogenic isoform
Pinus sylvestris
5739
-
mitochondrion
ketogenic isoform
Rattus norvegicus
5739
-
mitochondrion
ketogenic isoform
Saccharomyces cerevisiae
5739
-
mitochondrion
ketogenic isoform
Schizosaccharomyces pombe
5739
-
mitochondrion
ketogenic isoform
Sus scrofa
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + acetoacetyl-CoA + H2O
Methanothermobacter thermautotrophicus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Mesocricetus auratus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Arabidopsis thaliana
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Blattella germanica
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Borreliella burgdorferi
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Caenorhabditis elegans
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Cricetulus griseus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Gallus gallus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Homo sapiens
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Mus musculus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Pinus sylvestris
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Rattus norvegicus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Saccharomyces cerevisiae
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Schizosaccharomyces pombe
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Sus scrofa
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
Gallus gallus
key intermediate in cholesterogenic and ketogenic pathways, cholesterogenic isoform in cytosol, ketogenic isoform in mitochondria, committed step for both pathways
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
ir
acetyl-CoA + acetoacetyl-CoA + H2O
Homo sapiens
key intermediate in cholesterogenic and ketogenic pathways, cholesterogenic isoform in cytosol, ketogenic isoform in mitochondria, committed step for both pathways
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
ir
acetyl-CoA + acetoacetyl-CoA + H2O
Saccharomyces cerevisiae
key intermediate in cholesterogenic and ketogenic pathways, cholesterogenic isoform in cytosol, ketogenic isoform in mitochondria, committed step for both pathways
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
ir
Purification (Commentary) (protein specific)
Commentary
Organism
several mutants partially purified
Gallus gallus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Gallus gallus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
ir
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Homo sapiens
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
ir
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Saccharomyces cerevisiae
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
ir
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Methanothermobacter thermautotrophicus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Mesocricetus auratus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Arabidopsis thaliana
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Blattella germanica
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Borreliella burgdorferi
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Caenorhabditis elegans
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Cricetulus griseus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Gallus gallus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Homo sapiens
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Mus musculus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Pinus sylvestris
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Rattus norvegicus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Saccharomyces cerevisiae
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Schizosaccharomyces pombe
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488117
Sus scrofa
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
-
acetyl-CoA + acetoacetyl-CoA + H2O
key intermediate in cholesterogenic and ketogenic pathways, cholesterogenic isoform in cytosol, ketogenic isoform in mitochondria, committed step for both pathways
488117
Gallus gallus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
ir
acetyl-CoA + acetoacetyl-CoA + H2O
key intermediate in cholesterogenic and ketogenic pathways, cholesterogenic isoform in cytosol, ketogenic isoform in mitochondria, committed step for both pathways
488117
Homo sapiens
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
ir
acetyl-CoA + acetoacetyl-CoA + H2O
key intermediate in cholesterogenic and ketogenic pathways, cholesterogenic isoform in cytosol, ketogenic isoform in mitochondria, committed step for both pathways
488117
Saccharomyces cerevisiae
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
-
-
ir
acetyl-CoA + H2O
-
488117
Gallus gallus
acetate + CoA
-
-
-
?
Other publictions for EC 2.3.3.10
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736321
Chang
-
Research advance of 3-hydroxy- ...
Artemisia annua, Camellia sinensis, Chara vulgaris, Medicago truncatula, Panax ginseng, Picrorhiza kurrooa, Ricinus communis, Siraitia grosvenorii, Theobroma cacao
J. Anim. Plant Sci.
25
1441-1450
2015
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9
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9
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9
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9
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-
-
736677
Mathews
Mutation of 3-hydroxy-3-methyl ...
Danio rerio
J. Neurosci.
34
3402-3412
2014
-
-
-
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1
-
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1
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2
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1
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2
-
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1
-
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-
-
-
-
-
-
-
1
1
-
-
-
736848
Liu
Cloning and characterisation o ...
Tripterygium wilfordii
Molecules
19
19696-19707
2014
-
-
1
-
-
-
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1
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4
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2
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1
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1
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1
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1
-
-
736978
Liao
Past achievements, current sta ...
Arabidopsis thaliana, Brassica juncea, Camptotheca acuminata, Catharanthus roseus, Gallus gallus, Hevea brasiliensis, Homo sapiens, Melampsora larici-populina, Mesocricetus auratus, Pinus sylvestris, Populus trichocarpa x Populus deltoides, Rattus norvegicus, Salvia miltiorrhiza, Solanum lycopersicum, Sus scrofa, Taxus x media
Plant Cell Rep.
33
1005-1022
2014
-
-
-
-
-
-
16
-
16
-
1
16
-
25
-
-
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-
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1
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16
1
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-
-
-
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-
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-
-
-
-
-
16
-
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16
-
1
16
-
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1
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-
16
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737147
Liao
Transgenic tobacco overexpress ...
Brassica juncea
PLoS ONE
9
e98264
2014
-
-
1
-
1
-
-
-
1
-
1
1
-
10
-
-
-
-
-
3
-
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1
1
-
-
-
-
-
-
-
-
-
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1
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1
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-
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1
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1
1
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-
-
-
-
3
-
-
1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
726092
Satoh
Overexpression of hydroxymethy ...
Rattus norvegicus
Pancreas
42
475-482
2013
-
-
-
-
-
-
-
-
1
-
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1
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2
-
-
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-
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2
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1
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1
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2
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
727772
VanNice
Expression in Haloferax volcan ...
Haloferax volcanii, Haloferax volcanii DSM 3757
J. Bacteriol.
195
3854-3862
2013
-
-
1
-
-
-
3
2
2
1
2
2
-
7
-
-
1
-
-
-
-
-
4
1
2
-
1
1
2
-
-
-
1
-
-
-
-
1
-
-
-
-
-
3
1
2
2
1
2
2
-
-
-
1
-
-
-
-
4
1
2
-
1
1
2
-
-
-
-
1
1
-
1
1
737238
Kai
-
Molecular cloning and expressi ...
Camptotheca acuminata
Russ. J. Plant Physiol.
60
131-138
2013
-
-
-
-
-
-
-
-
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1
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1
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1
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1
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1
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1
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1
-
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-
-
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-
-
-
-
-
-
-
-
718933
Skaff
Biochemical and structural bas ...
Enterococcus faecalis
Biochemistry
51
4713-4722
2012
-
-
1
1
-
-
1
-
-
-
-
-
-
3
-
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1
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-
-
-
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1
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1
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1
-
1
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1
1
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
720426
Puisac
Characterization of splice var ...
Homo sapiens
Mol. Biol. Rep.
39
4777-4785
2012
-
-
1
-
-
-
-
-
1
-
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-
2
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-
-
-
-
15
-
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1
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-
-
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-
-
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-
-
-
1
-
-
-
-
-
-
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-
1
-
-
-
-
-
-
-
-
15
-
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1
-
-
-
-
-
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-
-
-
-
-
-
-
-
720647
Wang
Overexpression of Brassica jun ...
Brassica juncea
Plant Biotechnol. J.
10
31-42
2012
-
-
1
-
3
-
1
-
1
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-
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4
-
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-
-
-
-
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1
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1
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3
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1
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1
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1
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-
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2
2
-
-
-
701677
Andrew Skaff
A visible wavelength spectroph ...
Homo sapiens
Anal. Biochem.
396
96-102
2010
-
1
1
-
-
-
6
3
-
-
-
1
-
2
-
-
1
-
-
-
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1
-
2
-
-
-
1
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1
3
-
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1
1
1
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-
-
-
6
3
3
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-
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1
-
-
-
1
-
-
-
-
1
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
706004
Yi
Mitochondrial HMG-CoA synthase ...
Rattus norvegicus
Nutrition
26
1176-1180
2010
-
-
-
-
-
-
-
-
2
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-
1
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2
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2
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1
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1
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1
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2
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1
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2
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1
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-
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1
-
-
1
-
-
706551
Okamura
Unprecedented acetoacetyl-coen ...
no activity in Streptomyces albus
Proc. Natl. Acad. Sci. USA
107
11265-11270
2010
-
-
-
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-
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3
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
720239
Shafqat
Crystal structures of human HM ...
Homo sapiens
J. Mol. Biol.
398
497-506
2010
-
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1
1
17
-
-
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2
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-
5
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1
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-
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4
-
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2
-
2
17
-
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2
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2
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-
4
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-
-
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-
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-
-
-
-
-
706809
Battilana
The 1-deoxy-D: -xylulose 5-pho ...
Vitis vinifera x Vitis riparia, Vitis vinifera x Vitis vinifera
Theor. Appl. Genet.
118
653-669
2009
-
-
-
-
-
-
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2
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-
-
2
2
-
-
-
688996
Liu
A natural polymorphism in pero ...
Homo sapiens
Mol. Endocrinol.
22
1078-1092
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
1
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1
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1
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1
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1
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1
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-
-
-
-
706833
Andringa
Mitochondrial protein thiol mo ...
Mus musculus
Toxicol. Lett.
177
188-197
2008
-
1
-
-
-
-
-
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1
-
1
1
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1
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1
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1
2
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1
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1
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1
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1
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1
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1
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1
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1
1
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1
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1
2
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1
-
1
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-
1
-
-
-
1
-
-
1
-
-
687002
Castro
Increased activity of hepatic ...
Homo sapiens
Hepatology
45
1261-1266
2007
-
-
-
-
-
-
-
-
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3
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1
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1
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-
-
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-
-
-
-
-
-
-
-
672101
Steussy
A structural limitation on enz ...
Enterococcus faecalis
Biochemistry
45
14407-14414
2006
-
-
-
1
1
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-
-
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-
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2
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1
1
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-
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-
-
-
-
-
-
-
-
674016
Bearfield
Isolation, endocrine regulatio ...
Ips pini
Insect Mol. Biol.
15
187-195
2006
-
-
1
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1
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4
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1
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1
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1
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1
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-
674300
Bode
3-Hydroxy-3-methylglutaryl-coe ...
Myxococcus xanthus
J. Bacteriol.
188
6524-6528
2006
-
-
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1
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1
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4
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1
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1
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1
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1
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-
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-
-
-
675910
Camarero
Ketogenic HMGCS2 Is a c-Myc ta ...
Homo sapiens
Mol. Cancer Res.
4
645-653
2006
-
1
-
-
-
-
-
-
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-
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2
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676805
Pojer
Structural basis for the desig ...
Brassica juncea
Proc. Natl. Acad. Sci. USA
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11491-11496
2006
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660322
Sirinupong
Molecular cloning of a new cDN ...
Hevea brasiliensis
Planta
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2005
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2
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3
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-
660323
Nagegowda
Brassica juncea HMG-CoA syntha ...
Brassica juncea, Brassica juncea BjHMGS1, Brassica juncea BjHMGS2, Brassica juncea BjHMGS3, Brassica juncea BjHMGS4
Planta
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2005
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1
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9
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671988
Steussy
X-ray crystal structures of HM ...
Enterococcus faecalis
Biochemistry
44
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2005
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-
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1
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1
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6
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657850
Nagegowda
Brassica juncea 3-hydroxy-3-me ...
Brassica juncea
Biochem. J.
383
517-527
2004
1
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1
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8
-
7
11
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1
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1
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5
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1
1
1
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8
1
1
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11
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1
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8
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1
7
11
11
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1
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1
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1
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2
1
1
1
-
8
1
1
-
-
-
-
-
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658185
Tomoda
Binding site for fungal beta-l ...
Cricetinae, Rattus norvegicus
Biochim. Biophys. Acta
1636
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2004
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1
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3
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1
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2
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1
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659403
Campobasso
Staphylococcus aureus 3-hydrox ...
Staphylococcus aureus
J. Biol. Chem.
279
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2004
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1
1
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1
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2
1
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-
488123
Misra
-
The influence of conserved aro ...
Gallus gallus
J. Biol. Chem.
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2003
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1
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4
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1
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1
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1
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3
-
-
-
-
-
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-
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-
-
-
488122
Sutherlin
Enterococcus faecalis 3-hydrox ...
Blattella germanica, Borreliella burgdorferi, Bos taurus, Enterococcus faecalis, Gallus gallus, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Streptococcus pneumoniae, Streptococcus pyogenes, Streptomyces sp., Sus scrofa
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2002
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2
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5
1
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18
4
1
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1
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2
2
4
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5
15
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4
16
-
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2
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5
1
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18
4
1
-
-
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1
-
-
-
-
-
-
-
-
-
488120
Barrero
Low activity of mitochondrial ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley, Sus scrofa
Arch. Biochem. Biophys.
385
364-371
2001
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2
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2
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2
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3
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2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
488121
Casals
3-Hydroxy-3-methylglutaryl coe ...
Blattella germanica
Insect Biochem. Mol. Biol.
31
425-433
2001
-
-
1
-
-
-
-
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1
-
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1
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2
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1
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3
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1
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1
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1
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1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
488117
Chun
3-Hydroxy-3-methylglutaryl-CoA ...
Arabidopsis thaliana, Blattella germanica, Borreliella burgdorferi, Caenorhabditis elegans, Cricetulus griseus, Gallus gallus, Homo sapiens, Mesocricetus auratus, Methanothermobacter thermautotrophicus, Mus musculus, Pinus sylvestris, Rattus norvegicus, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Sus scrofa
Biochemistry
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2000
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1
1
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-
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3
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21
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21
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1
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-
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25
-
-
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-
-
-
-
-
-
-
-
1
1
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-
-
-
-
3
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20
44
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-
21
-
-
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1
-
-
-
-
25
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
488118
Chun
3-hydroxy-3-methylglutaryl-CoA ...
Arabidopsis thaliana, Blattella germanica, Borreliella burgdorferi, Gallus gallus, Homo sapiens, Methanothermobacter thermautotrophicus, Mus musculus, Pinus sylvestris, Rattus norvegicus, Schizosaccharomyces pombe, Sus scrofa
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2000
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1
2
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2
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2
14
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14
-
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1
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-
-
-
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14
2
-
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-
-
-
-
-
-
-
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1
2
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-
-
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2
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5
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2
14
-
-
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1
-
-
-
-
14
2
-
-
-
-
-
-
-
-
-
-
-
-
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488119
Vinarov
3-Hydroxy-3-methylglutaryl-coe ...
Gallus gallus
Biochemistry
39
3360-3368
2000
-
-
1
-
-
-
-
-
-
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1
-
2
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1
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2
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1
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1
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1
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1
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2
-
-
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-
1
-
-
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-
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660160
Alex
Expression of Brassica juncea ...
Brassica juncea
Plant J.
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415-426
2000
-
-
1
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-
-
5
-
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2
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-
-
-
-
-
-
-
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1
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1
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1
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-
-
5
-
-
2
-
-
-
-
-
-
-
-
-
-
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657803
Hegardt
Mitochondrial 3-hydroxy-3-meth ...
Rattus norvegicus, Sus scrofa
Biochem. J.
338
569-582
1999
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-
-
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6
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6
-
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-
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Madsen
Mitochondrial 3-hydroxy-3-meth ...
Rattus norvegicus
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57
1011-1019
1999
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-
-
-
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1
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1
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1
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1
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-
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-
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Tachibana
-
Non-radiochemical 3-hydroxy-3 ...
Pyrococcus furiosus
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523-526
1998
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1
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1
1
1
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-
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-
-
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1
-
1
1
1
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488116
Cabano
Catalytic properties of recomb ...
Blattella germanica, Bos taurus, Diploptera punctata, Gallus gallus, Locusta migratoria, Saccharomyces cerevisiae
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27
499-505
1997
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1
-
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2
7
4
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1
6
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9
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1
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6
1
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10
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
2
2
7
4
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1
6
-
-
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1
-
6
1
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
488115
Misra
Evidence for the interaction o ...
Blattella germanica, Bos taurus, Gallus gallus, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae
Biochemistry
35
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1996
-
1
1
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1
15
10
-
-
9
-
10
-
-
-
-
-
4
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
15
10
-
-
9
-
-
-
-
-
4
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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488112
Misra
Avian cytosolic 3-hydroxy-3-me ...
Blattella germanica, Cricetulus griseus, Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus
Biochim. Biophys. Acta
1247
253-259
1995
-
-
1
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-
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6
9
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7
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7
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1
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-
-
-
-
8
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
6
10
-
-
7
-
-
-
1
-
-
-
-
8
-
-
-
-
-
1
1
-
-
-
-
-
-
-
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488113
Montamat
Isolation and characterization ...
Arabidopsis thaliana, Catharanthus roseus, Cricetulus griseus, Gallus gallus, Homo sapiens, Raphanus sativus, Rattus norvegicus
Gene
167
197-201
1995
-
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1
-
-
-
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1
-
6
7
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9
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1
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5
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8
-
-
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-
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1
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1
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6
7
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1
-
5
-
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8
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-
-
-
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-
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-
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488114
Scharnagl
A novel assay of cytosolic 3-h ...
Bos taurus, Cricetulus griseus, Gallus gallus, Homo sapiens, Mesocricetus auratus, Rattus norvegicus
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1995
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2
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2
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7
1
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6
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1
4
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2
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8
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1
6
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2
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7
1
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6
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-
-
-
-
-
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488111
Rokosz
Human cytoplasmic 3-hydroxy-3- ...
Cricetulus griseus, Gallus gallus, Homo sapiens, Rattus norvegicus
Arch. Biochem. Biophys.
312
1-13
1994
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8
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7
1
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4
2
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2
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1
1
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2
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10
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1
4
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1
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7
1
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4
2
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-
-
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488109
Greenspan
-
Inhibition of 3-hydroxy-3-meth ...
Mesocricetus auratus, Mus musculus, Rattus norvegicus
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289
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1993
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3
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3
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1
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2
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3
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Misra
Avian 3-hydroxy-3-methylglutar ...
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3
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1
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1
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2
1
1
2
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1
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3
3
2
3
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Mayer
Inhibition of 3-hydroxy-3-meth ...
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169
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1
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1
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1
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1
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Miziorko
3-Hydroxy-3-methylglutaryl-CoA ...
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110
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1988
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3
3
1
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1
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2
1
2
4
1
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2
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3
2
3
1
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2
1
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1
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2
1
2
4
1
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488106
Greenspan
Inhibition of hydroxymethylglu ...
Cricetulus griseus, Gallus gallus, Homo sapiens, Rattus norvegicus
Proc. Natl. Acad. Sci. USA
84
7488-7492
1987
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-
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2
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9
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4
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6
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1
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3
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5
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9
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5
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488103
Lowe
3-Hydroxy-3-methylglutaryl-coe ...
Bos taurus, Gallus gallus, Saccharomyces cerevisiae
Biochem. J.
227
591-599
1985
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1
8
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5
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7
3
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3
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1
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2
1
1
4
2
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1
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1
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8
1
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5
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7
3
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1
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2
1
1
4
2
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1
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488104
Lowe
Succinylation and inactivation ...
Bos taurus
Biochem. J.
232
37-42
1985
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2
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1
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1
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1
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2
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1
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488105
Miziorko
-
Active-site directed inhibitio ...
Gallus gallus
Biochemistry
34
3174-3179
1985
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2
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1
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1
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1
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1
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1
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2
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2
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1
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1
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1
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1
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488102
Menahan
Interrelationships between 3-h ...
Gallus gallus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Eur. J. Biochem.
119
287-296
1981
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-
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2
3
4
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3
-
164
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1
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3
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4
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1
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1
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2
1
3
4
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3
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4
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1
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488101
Page
Some properties of 3-hydroxy-3 ...
Bos taurus, Gallus gallus, Saccharomyces cerevisiae
Biochem. J.
173
925-928
1978
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3
1
5
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1
3
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5
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2
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2
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4
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1
1
5
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1
3
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2
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2
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4
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488095
Clinkenbeard
-
Cytosolic 3-hydroxy-3-methylgl ...
Gallus gallus, Saccharomyces cerevisiae
Methods Enzymol.
35 B
160-167
1975
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-
-
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6
1
5
-
2
3
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2
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1
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1
1
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5
1
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1
1
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6
-
1
5
-
2
3
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1
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1
1
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5
1
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1
1
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488096
Clinkenbeard
-
Cyoplasmic 3-hydroxy-3-methylg ...
Columba livia, Gallus gallus, Meleagris gallopavo, Rattus norvegicus, Saccharomyces cerevisiae
J. Biol. Chem.
250
3124-3135
1975
1
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6
4
12
1
7
5
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5
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1
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7
1
4
12
1
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3
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1
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6
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4
12
1
7
5
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1
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7
1
4
12
1
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3
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488097
Middleton
-
3-Hydroxy-3-methylglutaryl-CoA ...
Saccharomyces cerevisiae
Methods Enzymol.
35 B
173-177
1975
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-
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-
1
7
3
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1
1
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1
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1
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1
2
6
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1
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1
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7
1
3
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1
1
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1
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1
2
6
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488098
Miziorko
3-Hydroxy-3-methylglutaryl coe ...
Gallus gallus, Saccharomyces cerevisiae
J. Biol. Chem.
250
5768-5773
1975
4
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1
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2
2
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2
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1
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1
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5
1
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1
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4
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1
1
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2
2
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1
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1
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5
1
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488099
Reed
Molecular and catalytic proper ...
Gallus gallus, Rattus norvegicus
J. Biol. Chem.
250
3117-3123
1975
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5
1
6
1
4
2
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3
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1
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2
1
1
3
1
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1
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5
1
1
6
1
4
2
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1
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2
1
1
3
1
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-
-
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488100
Reed
-
Mitochondrial 3-hydroxy-3-meth ...
Gallus gallus
Methods Enzymol.
35 B
155-160
1975
-
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-
1
1
2
1
-
2
1
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1
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1
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1
1
1
2
1
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1
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1
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2
1
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2
1
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1
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1
1
1
2
1
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488094
Cornforth
Substrate stereochemistry of 3 ...
Rattus norvegicus, Saccharomyces cerevisiae
Eur. J. Biochem.
42
591-604
1974
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2
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2
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1
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1
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4
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2
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1
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1
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4
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488093
Allred
Properties and subcellular dis ...
Cavia porcellus, Gallus gallus, Rattus norvegicus
Biochim. Biophys. Acta
297
22-30
1973
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2
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6
1
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3
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3
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3
12
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4
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2
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6
1
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3
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3
12
-
4
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488091
Middleton
The kinetic mechanism of 3-hyd ...
Saccharomyces cerevisiae
Biochem. J.
126
35-47
1972
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15
4
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1
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2
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1
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1
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4
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19
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15
19
4
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1
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1
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1
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4
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488092
Middleton
The purification and some prop ...
Saccharomyces cerevisiae
Biochem. J.
126
27-34
1972
-
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1
10
-
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1
1
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2
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1
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1
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3
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1
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10
-
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1
1
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1
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1
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3
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