Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,3-dimethylglutaryl-CoA | - |
Saccharomyces cerevisiae | |
3-oxohexanoyl-CoA | - |
Saccharomyces cerevisiae | |
acetoacetyl-CoA | substrate inhibition | Saccharomyces cerevisiae | |
butyryl-CoA | - |
Saccharomyces cerevisiae | |
CoA | - |
Saccharomyces cerevisiae | |
decanoyl-CoA | - |
Saccharomyces cerevisiae | |
desulfo-CoA | - |
Saccharomyces cerevisiae | |
DL-3-hydroxy-3-methylglutaryl-CoA | uncompetitive inhibition | Saccharomyces cerevisiae | |
DL-3-methylglutaryl-CoA | - |
Saccharomyces cerevisiae | |
glutaryl-CoA | - |
Saccharomyces cerevisiae | |
heptanoyl-CoA | - |
Saccharomyces cerevisiae | |
hexanoyl-CoA | - |
Saccharomyces cerevisiae | |
nonanoyl-CoA | - |
Saccharomyces cerevisiae | |
octanoyl-CoA | - |
Saccharomyces cerevisiae | |
propionyl-CoA | - |
Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0004 | - |
acetoacetyl-CoA | pH 8.0 | Saccharomyces cerevisiae | |
0.0032 | - |
acetoacetyl-CoA | pH 8.9 | Saccharomyces cerevisiae | |
0.014 | - |
acetyl-CoA | pH 8.0 | Saccharomyces cerevisiae | |
0.018 | - |
acetyl-CoA | pH 8.9 | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + acetoacetyl-CoA + H2O | Saccharomyces cerevisiae | synthesis of isoprenes and steroids | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
baker's yeast | - |
Purification (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2 | - |
- |
Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Saccharomyces cerevisiae | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir | |
acetyl-CoA + acetoacetyl-CoA + H2O | synthesis of isoprenes and steroids | Saccharomyces cerevisiae | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir | |
additional information | acetyl-CoA homologues do not act as substrates | Saccharomyces cerevisiae | ? | - |
? | |
additional information | absolutely specific for acetyl-CoA and acetoacetyl-CoA in the reaction, neither propionyl- nor butyryl-CoA can replace acetyl-CoA, no reaction observed when 3-oxohexanoyl-CoA is substituted for acetoacetyl-CoA | Saccharomyces cerevisiae | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0027 | - |
decanoyl-CoA | pH 8.0 | Saccharomyces cerevisiae | |
0.004 | - |
nonanoyl-CoA | pH 8.0 | Saccharomyces cerevisiae | |
0.005 | - |
propionyl-CoA | pH 8.0 | Saccharomyces cerevisiae | |
0.0071 | - |
3-oxohexanoyl-CoA | pH 8.0 | Saccharomyces cerevisiae | |
0.008 | - |
acetoacetyl-CoA | pH 8.0 | Saccharomyces cerevisiae | |
0.0081 | - |
octanoyl-CoA | pH 8.0 | Saccharomyces cerevisiae | |
0.0123 | - |
heptanoyl-CoA | pH 8.0 | Saccharomyces cerevisiae | |
0.013 | - |
DL-3-hydroxy-3-methylglutaryl-CoA | pH 8.0, competitive inhibition, substrate acetyl-CoA | Saccharomyces cerevisiae | |
0.014 | - |
3-oxohexanoyl-CoA | pH 8.0, mixed inhibition, substrate acetoacetyl-CoA | Saccharomyces cerevisiae | |
0.02 | - |
acetoacetyl-CoA | pH 8.9 | Saccharomyces cerevisiae | |
0.022 | - |
hexanoyl-CoA | pH 8.0 | Saccharomyces cerevisiae | |
0.03 | - |
desulfo-CoA | pH 8.0 | Saccharomyces cerevisiae | |
0.033 | - |
butyryl-CoA | pH 8.0 | Saccharomyces cerevisiae | |
0.038 | - |
CoA | pH 8.0, mixed inhibition, substrate acetyl-CoA | Saccharomyces cerevisiae | |
0.06 | - |
CoA | pH 8.0, mixed inhibition, substrate acetoacetyl-CoA | Saccharomyces cerevisiae | |
0.07 | - |
desulfo-CoA | pH 8.0, mixed inhibition, substrate acetoacetyl-CoA | Saccharomyces cerevisiae | |
0.1 | - |
DL-3-methylglutaryl-CoA | pH 8.0 | Saccharomyces cerevisiae | |
0.11 | - |
glutaryl-CoA | pH 8.0 | Saccharomyces cerevisiae | |
0.12 | - |
3,3-dimethylglutaryl-CoA | pH 8.0 | Saccharomyces cerevisiae |