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Literature summary for 2.3.2.33 extracted from
- The Ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics (2007), Neuron, 56, 604-620 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microtubule | Phr1 is associated with the microtubule cytoskeleton within neurons and selectively localizes to axons | Mus musculus | 5874 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q7TPH6 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neuron | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MYCBP2 | - |
Mus musculus |
| PHR1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Magellan mutant embryos, having a truncated Phr1 protein, motor axons are error prone and wander inefficiently at choice points within embryos. Motor and sensory neurons from Magellan mutants display abnormal morphologies due to a breakdown in the polarized distribution of components that segregate between axons and growth cones. The Magellan phenotype can be reversed by stabilizing microtubules with taxol or inhibiting p38-MAPK activity | Mus musculus |
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