Literature summary for 2.3.2.33 extracted from

James, G.; Key, B.; Beverdam, A.
The E3 ubiquitin ligase Mycbp2 genetically interacts with Robo2 to modulate axon guidance in the mouse olfactory system (2014), Brain Struct. Funct., 219, 861-874 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q7TPH6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	olfactory sensory neuron	Mus musculus	-
olfactory bulb	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	mice heterozygous for either Mycbp2 or receptor Robo2 are normal, mice double heterozygous for the two genes produce defects in dorsoventral topography in the olfactory bulb. Loss of Mycbp2 function leads to the loss of molecular identity of a subpopulation of olfactory sensory axons that normally express ROBO2. In addition, double heterozygous mice show complete absence of the hippocampal commissure	Mus musculus

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Release 2023.1 (January 2023)